(PRWEB) January 13, 2002
Mice treated with the drug Genuflex show a reversal in the effects of aging, according to the preliminary results of a study released Wednesday by the Santa Rosa Institute of Albuquerque, New Mexico.
Researchers at the Institute looked at 200 mice with a median age of 90 weeks at the beginning of the study (mice live an average of 118 weeks). Half of the mice were treated with daily doses of Genuflex, also known as Telomer Shield Factor, while the other half did not receive the drug. The mice were observed for changes over a period of 90 days. The mice DNA was then examined by gel electrophoresis and two-dimensional NMR imaging.
Results showed that the mice receiving Genuflex had stronger bones and brighter coats than the mice in the other group. The mice in the Genuflex group also experienced improvements in appetite and eyesight. The mice not receiving Genuflex suffered from brittle bones, hunchback, thinning hair and shrinkage of muscles and other body parts. In addition, the mice not receiving Genuflex lost weight and recovered poorly from wounds and infections. Examination of the DNA of the two mice groups showed that mutations due to chromosomal damage were actually reversed in the mice receiving Genuflex. The mice receiving Genuflex exhibited no serious side effects.
"This study offers the clearest, most conclusive evidence so far of Genuflex' promise in reversing the effects of aging," said Institute CEO Edward Westhead, M.D., Ph.D. "The results of our study confirm what we had discovered in the lab: Genuflex protects DNA from damage."
Genuflex is thought to works in two ways. First, it restores telomers, the protein caps on the end of the chromosome that protect DNA from damage and mutation during cell division. Second, Genuflex appears to suppress the p-53 gene, which is known as the "death gene" and is thought to trigger the cellular destruction that is a salient feature of aging.
The Santa Rosa researchers are also conducting long-term studies of another group of mice, the results of which should be available in June.
The Santa Rosa Institute is focused on ways to use genetic engineering to increase the human life span. The Institute is celebrating its Fiftieth Anniversary this year.