ULTRA PURE siRNA OLIGO TECHNOLGOY by Elchrom Scientific

Elchrom Scientific introduces a novel purification technology enabling to obtain ultra-pure siRNA synthetic oligonucleotides. The new technology delivers high performance in terms of purity (typically 98%), yield (typically 60% of the incoming full length oligo has been recovered at the above mentioned purity level in in-house tests), and turn-around time (typically 3 hours)

(PRWEB) August 8, 2004 -- Elchrom Scientific introduces a novel purification technology enabling to obtain ultra pure siRNA synthetic oligonucleotides.

The new technology delivers high performance in terms of purity (typically 98%), yield (typically 60% of the incoming full length oligo has been recovered at the above mentioned purity level in in-house tests), and turn-around time (typically 3 hours).

A newly developed hydrogel system from Elchrom Scientific allows purification of small RNA oligonucleotide duplexes as well as singleplexes. The new hydrogel system resolves RNA duplexes from singleplexes according to their structural differences, in addition to their size. These properties lead to ultrapure siRNA products. Labeled siRNA duplexes can also be purified effectively.

Additional advantages enabled by the new technology are quality control by MALDI-TOF Mass Spectrometry analysis for all oligos up to 120 mer, and hydrogel excision in blue light which prevents the oligonucleotide from degradation.

The new technology is based on Elchrom Scientifics proprietary process and Hydrogel patents whose superior qualities have been demonstrated for the recovery of highest purity DNA and RNA synthetic oligonucleotides.
Elchrom Scientific combines a non-toxic hydrogel electrophoresis system with a revolutionary elution technology, resulting in higher yields and improved quality compared to PAGE (polyacrylamide gel electrophoresis, up to now the standard gel purification technology).

Highest purity oligonucleotides produced with Elchrom Scientifics proprietary process and hydrogel meet the needs of the most demanding genomics and therapeutic applications.

This new application line will provide our customers with a complete portfolio of industrial solutions for the recovery of ultrapure oligonucleotides (DNA RNA and siRNA) on an industrial scale" says Jean-Louis Roux dit Buisson, Chief Executive Officer of Elchrom Scientific. "We are pleased to be pioneers in providing high throughput, high quality siRNA recovery and purification technologies on an industrial scale. Elchrom Scientific owns a reputation for excellence in quality of products and customer service developed in Academia and Research organizations with its DNA and RNA analytical solutions. The new application line which comes in complement to our DNA recovery and purification technologies will contribute to build a strong Industry Division extending further our values of quality and customer service".

Elchrom Scientific is a privately owned Swiss company that applies its core life science competencies to the development of innovative technologies for the analysis and processing of biological macromolecules. Elchrom Scientifics solutions are based upon its proprietary Hydrogel technology platform and 95/24 solutions.

For additional information please contact:
Quincy Mattingly
Director of Business Development & Marketing
Elchrom Scientific
Gewerbestrasse 8
CH 6330 Cham
Switzerland
Phone: + 41 41 747 25 50
Fax: + 41 41 743 25 36
http://www.elchrom.com
mailto://qmattingly@elchrom.com