Research And Markets: Have We Rediscovering The Importance Of Drug Structure For Drug Discovery?

(PRWEB) December 8, 2004 -- Structure-based drug design is perhaps the most elegant approach for discovering compounds exhibiting high specificity and efficacy. In reality, drug targets are very complex and this approach has had only limited utility. However, a number of recent successful drugs have in part or in whole emerged from a structure-based research approach. This Report describes the many advances including crystallography and informatics that are behind these successes. The Report also discusses the impact these advances in structure-based drug design are likely to have on the economics of drug discovery.

Research and Markets (http://www.researchandmarkets.com/reports/c10653) has announced the addition of Structure-Guided Drug Design: Rediscovering the Importance of Drug Structure for Drug Discovery to their offering

Current Status of the Pharmaceutical Industry:

The pharma industry is in a bad way. There are three major reasons for this self-inflicted malaise:

- a total preoccupation with the next blockbuster at the expense of other projects,
- an obsession with technological innovation leading to an arms-race," and
- an unsustainable strategy for improving corporate status by buying up the competition.

These are fundamental problems that cannot be resolved by new concepts of drug design. But the rediscovery of the importance of structure, especially in molecular interactions, can be a conceptual focus for restructuring the pharma industry for a new period of sustained growth.
Structure-guided drug design is a guide to the rediscovery of the importance of structure, for the whole of the drug discovery pipeline. It is not a report on how drug discovery used to be done in the past, but how it will be done in the future.

The contents of this report are as follows:

Chapter 1: Executive Summary                                                                    
Chapter 2: Drug Discovery In Context                                                        
Chapter 3: Hormones And Receptors                                                        
Chapter 4: The Combinatorial Explosion or High-Throughput
Chapter 5: Molecular Interactions and Virtual Drug Design                
Chapter 6: The Modern Synthesis: Bringing It All Together                    
Chapter 7: Future Prospects    

List of Exhibits                                                                

For more information visit http://www.researchandmarkets.com/reports/c10653

Laura Wood
Senior Manager
Research and Markets
press@researchandmarkets.com
Fax: +353 1 4100 980

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