Covalys Biosciences and Cisbio International Announce Collaboration to Combine SNAP-tag™ and HTRF® Technologies

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Covalys Biosciences AG and Cisbio international today announced a collaboration to develop products combining Covalys� SNAP-tag protein labeling system with Cisbio�s homogeneous time resolved fluorescence (HTRF®) technology.

Witterswil, Switzerland and Bagnols-sur-Cèze, France Covalys Biosciences AG and Cisbio international today announced a collaboration to develop products combining Covalys’ SNAP-tag protein labeling system with Cisbio’s homogeneous time resolved fluorescence (HTRF®) technology. These products will enable HTRF users to take advantage of the novel protein labeling technology enabled by the SNAP-tag.

Cisbio’s homogenous time-resolved fluorescence (HTRF®) system is a highly sensitive, robust technology for the detection of molecular interactions of proteins in vitro. It is widely used by the pharmaceutical industry for the high-throughput screening (HTS) stage of drug development. The SNAP-tag is an intelligent self-labeling protein tag which covalently links chemical probes to proteins of interest without prior purification. Under the agreement, Covalys receives the right to develop and sell SNAP-tag substrates containing Cisbio’s long-lifetime fluorophores (cryptates) which are essential for the development of HTRF® assays. SNAP-tag’s ability to label proteins without prior purification means that the resulting products will enable faster and simpler labeling of proteins with cryptates.

"By including Cisbio international’s well-known cryptates into our selection of SNAP-tag substrates we can expand our product portfolio in an area that is important to the High Throughput Screening world," said Dr Christoph Bieri, Covalys’ CEO. "We believe that our SNAP-tag technology can help to further enhance the utility of the powerful HTRF® technology."

"SNAP-tag represents a smart alternative to conventional chemical labeling and perfectly combines with the streamlined assay development procedures which HTRF® already offers to its customers," said Berthold Baldus, Managing Director of Cisbio In Vitro Technologies.

Covalys already offers a broad range of products to fluorescently label proteins using the SNAP-tag, both for live cell imaging and for protein-protein interaction assays in solution. The first products containing SNAP-tag substrate with Cisbio international’s cryptate are under development and will be made commercially available by Covalys during the second quarter of 2005.

About Covalys Biosciences AG:

Covalys provides products that help researchers in academic institutions and pharmaceutical and biotech companies to improve the efficiency of research into proteins and their function. Its SNAP-tag technology is the first commercially available protein tag which covalently links itself to any chemical probe provided as a substrate. Covalys’ technology is exclusively licensed from the Swiss federal Institute of Technology Lausanne (EPFL). Founded in June 2002, Covalys has headquarters in Witterswil, Switzerland. For more information, visit Covalys’ website:

About Cisbio international:

Cisbio international is an established developer of technologies that are used in assay development and drug screening procedures to enhance drug discovery. The company is also a pioneer in the field of homogenous fluorescence methodologies via its proprietary technology, HTRF®, and produces a selection of biological reagents and methods used by pharmaceutical and biotechnology companies, as well as contract research organizations (CROs). In addition, Cisbio international develops, manufactures and markets antibody-based diagnostic assays for the quantification of tumor markers and other biomarkers in clinical biology. For more information about Cisbio international and HTRF®, log onto

Trademarks: SNAP-tag is a registered trademark of Covalys Biosciences AG. HTRF® is a registered trademark of Cisbio international.

Media Contact:

Tom Gibbs

Covalys Biosciences AG

Phone     +41 (0)61 725 20 50

Colette Ballou    

Ballou PR/Cisbio international

Phone     +33 (0)1 42 22 24 10

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Tom Gibbs
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