Important New Data Presented Validating The Potential Of New Toothpaste Technology To Protect Against Enamel Erosion And Inhibit Root Caries Erosion.

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New study presented at the 54th European Organization for Caries Research (ORCA) Congress, July 2007 confirms data also presented at the International Association of Dental Research (IADR), March 2007.

These studies reinforce a growing body of data that demonstrate both the protective and reparative potential of NovaMin. This adds to the clinically proven benefits of NovaMin against tooth sensitivity and gingivitis.

New study presented at the 54th European Organization for Caries Research (ORCA) Congress, July 2007 confirms data also presented at the International Association of Dental Research (IADR), March 2007.

Results from the aggressive in vitro erosion model presented at the ORCA congress showed that NovaMin® (Calcium Sodium Phosphosilicate compound) containing dentifrices protect against enamel erosion both with and without fluoride in this laboratory model using extracted human teeth. The NovaMin-containing paste was compared to a high fluoride paste (with 50% higher Fluoride levels than typical store-bought pastes) and provided more than doubled the level of protection, when both were compared to brushing without any toothpaste. The study attempted to model the oral environment of individuals with limited saliva function, as these individuals represent the highest cavity-risk group of adults. Hundreds of medicines, along with medical conditions like diabetes, Sjogren's syndrome and Parkinson's disease and certain cancer treatments all result in reduced saliva function and higher cavity risk. Combinations of fluoride and NovaMin in toothpastes also produced very favorable data in the study.

The previous root caries pH cycling model conducted with roots of human molars presented at the IADR showed similar potential of NovaMin® (Calcium Sodium Phosphosilicate compound) with and without fluoride to markedly inhibit root caries progression. In a laboratory model of normal salivary function, comparing to a popular store-bought fluoride toothpaste, the NovaMin-containing toothpaste showed very similar results, with double the protective ability when both products were compared to brushing with a placebo toothpaste.

"These studies reinforce a growing body of data that demonstrate both the protective and reparative potential of NovaMin. This adds to the clinically proven benefits of NovaMin against tooth sensitivity and gingivitis." Said Randy Scott, CEO of NovaMin Technology Inc. He continued: "The effects of NovaMin-containing pastes without Fluoride compare extremely favorably to fluoride toothpaste. We continue to also be excited about the combination of fluoride and NovaMin as a new gold-standard for cavity prevention."

About NovaMin®

NovaMin addresses the rapidly growing, unmet oral care needs of adults and seniors. It does this by amplifying the natural biological defenses and repair mechanisms of the oral environment - resulting in teeth and gums that look healthier, feel healthier and are healthier.

NovaMin reverses the negative effects of time and age on teeth, combining essential minerals in their rare ionic form with saliva to form a new layer of tooth mineral. NovaMin is a non-toxic compound made from elements which are naturally critical for bone and tooth mineralization: calcium, phosphorus, silica, and sodium. Delivered in their common forms, these elements have very limited value in tooth health. However, delivered together, in their rare ionic form, makes them into powerhouses of tooth renewal.

Each microscopic NovaMin® particle serves as a delivery system for these ions. When the particle is exposed to water (from your saliva or tap water) it instantly reacts - releasing billions of mineral ions that become available to the natural remineralization process in your mouth. It is this natural process that is the ideal re-builder of tooth mineral. These ions, along with naturally occurring ions in your saliva, combine to form hydroxyapatite crystals, the special form of hard and strong mineral in your teeth. No other man-made material is known to directly lead to the formation of these crystals in the body. For more information visit http://www.novamin.com.

Oral Care Market and the "Second Half of Life"

Fifty years after the wide-spread adoption of fluoride in everything from toothpaste to water supplies, scientists have recognized the need for improved adult tooth care and have created new technologies to address it. There are several new materials becoming available to toothpaste and dental products marketers that have the promise to fill this need. This has set off a scramble to define a new technology standard in the $30 billion worldwide dental hygiene marketplace, made up of toothpaste and a broad array of other products sold in the supermarket, pharmacy and dental office. A race to define a "new technology standard" normally conjures up the consumer electronics (Blu-Ray vs. High Def) or information technology (Mac vs. Windows) industries - but in this case it also applies to something even more ubiquitous, toothpaste.

The previous 'gold standard' active ingredient for toothpaste has been fluoride. Originally adopted in the 1950's, fluoride hardens teeth to prevent acid damage. This was especially effective in earlier decades when diets were not as highly acidic and carbohydrate-rich as today. Skyrocketing consumption of sodas, sports drinks and even healthy things like fruit juice in the last few decades means that damage is inevitable - and the focus needs to shift to daily repair. The body has always had the ability to repair microscopic damage every day, before a dentist's drill is needed - but the process is slow and also intended for different diets. These new ingredient technologies all have a common theme: supplementing the body's own repair (remineralization) mechanism with minerals.

Aging Population
The NIA (National Institute on Aging) U.S. Bureau of the Census reported in August 29th, 2006, that the numbers of elderly are projected to double in 21 States between 1995 and 2025.

According to the U.S. Census Bureau, Population Division projections for 2005, the US population will growth to 308 million people in 2010. Nearly 48 % of the national population will be over 45 years old and the Baby Boom generation (those born between 1946 and 1964) will represent the 13.92%.

Mid-lifer Oral Care Issues

Remineralization Needs
Increased consumption of acidic beverages (soda, sports drinks) causes severe tooth wear and acid erosion, leading to higher bacterial activity and easier stain attachment.
"A recent survey of the Academy of General Dentistry (AGD) members revealed that dentists think tooth erosion is more common today compared to five years ago and many respondents stated that consuming soft drinks, as well as other foods with a low pH value (such as fruit juices, pickles, fresh fruit and yogurt), contribute to tooth erosion. Tooth erosion is the breakdown of tooth structure caused by the effect of acid on the teeth. Dental enamel is the thin, outer layer of hard tissue that helps maintain the tooth's structure and shape while protecting it from decay."

Adult Cavities
The dental care needs of older adults are different than that of young adults and children. This is related to the primary natural defense for the oral cavity: saliva. Salivary function and composition deteriorates with age. Age-related factors such as prescription drug use and type-II diabetes also contribute to oral health problems.

In fact, in the US (which has some of the highest standards of oral hygiene and access to dental care) filling cavities has reached its highest level ever - with over 150,000,000 filled every year at a cost in excess of $10 Billion. Once thought of as a childhood condition, tooth decay is now predominantly a condition of maturity. Over half of all cavities now occur in adults, mostly seniors.

Over the last 10-20 years caries rate has been increasing, due to the explosion of "Root Caries" and "Secondary Caries" among adults and seniors in particular. Recently, adult caries surpassed juvenile caries, and now represents the majority of caries cases.

The Centers for Disease Control has named dental caries, specifically in adults, as the #1 chronic disease in America, and the Surgeon General recently issued a report describing it as a critical public health issue.

Root caries:

  • ~ 1/3 of adults 45+ have active root caries
  • ~ 1/2 of adults 65+
  • Trend sharply up.

Sources:
1 A.K. Burwell and D.C. Greenspan, "Potential for Dentifrice Protection Against Enamel Erosion in an In Vitro Model", ORCA Abstract, July 2007.
2 J.D. Featherstone, M.L. Rapozo-Hilo, P. Rechmann, B. Rechmann, and D. Greenspan, "In Vitro Root Caries Inhibition by Phosphosilicate and Fluoride Dentifrices", J Dent Res. Issue 86, Abstract #0501, 2007.
3 Susan Urbanczyk of the Academy of General Dentistry.

For more information, please visit http://www.novamin.com or contact us at +1-386-418-1551.

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