CME Outfitters Announces neuroscienceCME Journal Club Series: "Bipolar Disorder: Individualizing Treatment to Improve Patient Outcomes"

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Offered as a series of three live question and answer sessions premiering Monday, November 17, 2008, from 12:00 p.m.-12:45 p.m. ET, the activity will incorporate the latest evidence-based literature to develop strategies for early detection, intervention, and long-term maintenance of patients with bipolar depression. Clinicians can earn up to 3.0 CE credits by completing all 3 parts.

CME Outfitters, LLC, an independent accredited provider of multidisciplinary medical education programming and related healthcare communications services, is pleased to announce an upcoming live and interactive evidence-based neuroscienceCME Journal Club series titled "Bipolar Disorder: Individualizing Treatment to Improve Patient Outcomes."

Premiering Monday, November 17, 2008, from 12:00 p.m.-12:45 p.m. ET, the latest installment of neuroscienceCME Journal Club is a special series on bipolar disorder. Roger S. McIntyre, MD, FRCPC, Associate Professor of Psychiatry and Pharmacology at the University of Toronto, will host three interviews on this topic. In each session, guest faculty will join Dr. McIntyre to provide a brief synopsis of a recently published scientific work. Dr. McIntyre and his guest will engage in a lively discussion about the merits of the article, its implications for the field of psychiatry, and key practice points arising from the data published in the article.

This educational activity consists of a series of three live question and answer sessions. Live participation options include a live webcast and simultaneous telephone audioconference. Each session will also be available as an archived webcast and podcast shortly after its premiere. Clinicians can earn up to 3.0 CE credits by completing all 3 parts.

There is no fee to participate or receive CE credit for this activity; however, registration is required. Three forms of registration are accepted:

Online: Visit the activity details page at and click the Register for Webcast icon. Links to register for each individual live Q&A session are also provided.

Phone: Call 877.CME.PROS (877.263.7767).
Fax: Visit the activity details page at, print and complete the activity details form, and fax to 240.243.1033.

Guest Host:
Roger S. McIntyre, MD, FRCPC
Associate Professor of Psychiatry and Pharmacology
University of Toronto
Head, Mood Disorders Psychopharmacology Unit
University Health Network
Toronto, ON

Robert M. Post, MD
Head, Bipolar Collaborative Network
Professor of Psychiatry
The George Washington University School of Medicine
Penn State University School of Medicine
Bethesda, MD

Trisha Suppes, MD, PhD
Professor, Department of Psychiatry and Behavioral Science
Stanford University School of Medicine
War Related Illness and Injury Study Center
VA Palo Alto Health Care System
Stanford, CA

Charles L. Bowden, MD
Nancy U. Karren Clinical Professor
Department of Psychiatry
University of Texas Health Science Center at San Antonio
San Antonio, TX

Live Q&A Dates and Featured Articles:
PART 1: Monday, November 17, 2008, 12:00-12:45 p.m. ET (Robert M. Post, MD/Roger S. McIntyre, MD, FRCPC)
Post RM. Role of BDNF in bipolar and unipolar disorder: clinical and theoretical implications. J Psychiatr Res. 2007;41:979-990.

PART 2: Tuesday, December 2, 2008, 12:00-12:45 p.m. ET (Trisha Suppes, MD, PhD/Roger S. McIntyre, MD, FRCPC)
Vieta E, Suppes T, Eggens I, Persson I, Paulsson B, Brecher M. Efficacy and safety of quetiapine in combination with lithium or divalproex for maintenance of patients with bipolar I disorder (international trial 126). J Affect Disord. 2008;109:251-263.

PART 3: Monday, December 15, 2008, 12:00-12:45 p.m. ET (Charles L. Bowden, MD/Roger S. McIntyre, MD, FRCPC)
Sachs GS, Nierenberg AA, Calabrese JR, et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med. 2007;356:1711-1722.

Statement of Need:
Bipolar disorder (BPD) is a chronic condition characterized by fluctuating episodes of manic, or mixed symptoms, and depression. A recent estimate of the annual prevalence of BPD in the US is 2.6%. BPD ranked as the 6th leading cause of disability worldwide in 1990. Despite the dominance of depressive symptoms and episodes over the course of both bipolar I and II disorder, and the more frequent functional impairment associated with bipolar depression, there has been a disproportionate lack of attention to establishing effective treatment and management of bipolar depression. Researchers continue to explore the best possible treatments for these patients, as well as the potential role of proteins such as brain-derived neurotrophic factor (BDNF) in predicting the onset and treatment of bipolar disorder. In this evidence-based neuroscienceCME Journal Club activity, experts will review the latest clinical literature in the field of bipolar disorder and translate this information into improved clinical outcomes for patients with BPD.

Learning Objectives:
At the end of this CE activity, participants should be able to:

  • PART 1: Assess the role of Brain Derived Neurotrophic Factor (BDNF) in both the pathophysiology and clinical presentations of bipolar and unipolar disorder.
  • PART 2: Compare the use of atypical antipsychotics in combination with mood stabilizers versus mood stabilizers plus placebo in patients with bipolar I disorder.
  • PART 3: Compare and contrast the use of adjunctive, antidepressant therapy and mood stabilizers with the use of mood stabilizers alone in achieving a durable recovery in BPD.

Target Audience:
Physicians, physician assistants, nurse practitioners, nurses, psychologists, social workers, certified case managers, pharmacists, and other healthcare professionals with an interest in mental health.

Commercial Support:
CME Outfitters, LLC, gratefully acknowledges an educational grant from AstraZeneca Pharmaceuticals in support of this CE activity.

Credit Information:
This activity offers CE credit for:

  • Physicians (ACCME/AMA PRA Category 1)
  • Nurses (CNE)
  • Pharmacists (ACPE)
  • Psychologists (APA)
  • Social Workers (NASW)
  • Certified Case Managers (CCMC)

All other clinicians will either receive a CME Attendance Certificate or may choose any of the types of CE credit being offered.

Post-tests, credit request forms, and activity evaluations can be completed online at (click on the Testing/Certification link under the Resources tab - requires free account activation), and participants can print their certificate or statement of credit immediately (70% pass rate required). Additional time for completing the post-test and evaluation will be added to each 45-minute presentation to equal 1.0 CE credit.

About CME Outfitters:
CME Outfitters develops and distributes live, recorded, print, and web-based educational activities to thousands of clinicians each year and offers expert accreditation services for non-accredited organizations. For a complete catalog of certified activities, please visit,, or call 877.CME.PROS (877.263.7767).

About neuroscienceCME: is the award-winning web portal serving clinicians, educators, and researchers in the neurosciences. Launched in October 2006, was custom designed to fill an identified gap in online resources for professionals around the world who are practicing in areas related to psychiatry, sleep disorders, addiction and substance abuse, ADHD, and other areas related to brain function. The site's primary mission is to be the professional's central forum for accessing, debating, synthesizing, and implementing the latest findings and best practices in the neurosciences.

About neuroscienceCME Journal Club:
neuroscienceCME Journal Club was designed for clinicians who have made a commitment to staying current. Each month, neuroscienceCME Journal Club will evaluate recently published literature and present it in a concise 45-minute audioconference+webcast format full of valuable takeaway points that can be immediately applied to clinical practice. To enhance their value as enduring clinical resources, all neuroscienceCME Journal Club segments are archived in their respective Clinical Knowledge Centers at The archives are updated frequently and indexed by date, topic, and guest author. Recorded Journal Club episodes are also offered as podcasts.

To view all recent neuroscienceCME press releases, visit and click on "News Room" or visit and search for "neuroscienceCME."

Clinical Compass, a bi-weekly e-newsletter published by CME Outfitters, is a convenient way to stay informed of all neuroscienceCME news and information. To subscribe, visit and click on "Subscribe to Clinical Compass."

Contact: Jessica Primanzon
CME Outfitters, LLC
240.243.1308 direct
240.243.1033 fax


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