Veterans Medical Research Foundation, Veterans Affairs (VA) San Diego Healthcare System and CVAC Systems, Inc. Sign Cooperative Research and Development Agreement

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Karen Herbst, MD, PhD is passionate about helping those with chronic metabolic disease. Initially, a pilot study using the CVAC™ process in veterans with diabetes is planned. A study on Dercum's disease--a disorder of painful fatty growths in the subcutaneous tissue--is also being planned.

We are pleased to work with Dr. Herbst and the VA San Diego Healthcare System, as they represent one of the most highly esteemed research organizations in the country. This significant milestone is direct evidence that the CVAC Systems team is capable of executing its focused strategic plan

CVAC Systems, Inc., the Veterans Medical Research Foundation and the VA San Diego Healthcare System have agreed to begin initial studies investigating the cyclic variations in altitude conditioning™(CVAC™) process for prevention and treatment of metabolic disorders, specifically those conditions resulting in elevations of blood sugar. Expanding on her passion for helping those at risk due to chronic metabolic disease, Karen Herbst, MD, PhD, is initially planning pilot studies using the CVAC process in veterans with diabetes, and with individuals suffering from Dercum's disease, a painful fat disorder. The CVAC process is natural and noninvasive and delivered via a single-occupant altitude simulator. A CVAC session is expected to provide exercise for the entire body without the effort of exercise. A CVAC system is now installed in the Center for Metabolic Research/Special Diagnostics Treatment Unit at the VA San Diego Healthcare System, which is headed by Robert R. Henry, MD.

Dr. Herbst's review of data from the blinded, controlled clinical trial completed by researchers at Stanford University Center on Longevity and the U.S. Department of Veterans Affairs Palo Alto Health Care System in July, 2008 convinced her to investigate the use of the CVAC process in the types of patients she treats. In that study, the subject group receiving active CVAC exposure for 40 minutes, three times a week over a 10-week period demonstrated a significant reduction in fasting blood glucose and a significant decrease in blood glucose during an oral glucose tolerance test. These changes were not seen in the control group.

Dr. Herbst and the Veterans Medical Research Foundation are open to collaborations with other investigators willing to write grants for investigating the use of the CVAC process, not limited to the fields of pulmonary medicine, rheumatology, neurology and cardiology.

"We are pleased to work with Dr. Herbst and the VA San Diego Healthcare System, as they represent one of the most highly esteemed research organizations in the country. This significant milestone is direct evidence that the CVAC Systems team is capable of executing its focused strategic plan," said Allen Ruszkowski, President & CEO of CVAC Systems, Inc.

About Karen L. Herbst, PhD, MD
Dr. Herbst is Assistant Professor of Medicine and Associate Program Director, Endocrinology at UCSD. She is affiliated at UCSD Medical Center, Hillcrest (San Diego) and the Center for Metabolic Research at the Veterans Affairs San Diego Healthcare System. Dr. Herbst's clinical interests are Dercum's disease, Adiposis dolorosa, Madelung's disease, familial multiple lipomatosis, testosterone deficiency and hypogonadism.

About CVAC Systems, Inc.
CVAC Systems, Inc. is a privately held medical device company headquartered in Temecula, CA focused on the application of its Cyclic Variations in Altitude Conditioning process to diseases and disorders associated with aging, including insulin resistance, diabetes, neuropathy, cardiovascular disease, Alzheimer's disease and declining testosterone levels. The company also provides licenses to partners that develop applications in corporate health and wellness.

Please note: The information contained within this document is intended for prospective researchers only, and is not intended for patients or health care providers. Any references to therapeutic applications are for discussion and research purposes only.

Copyright © 2009, CVAC Systems, Inc. All rights reserved. Cyclic Variations in Altitude Conditioning, CVAC and CVAC logo are trademarks or registered trademarks of CVAC Systems, Inc. in the United States and/or other Countries. All other trademarks belong to their respective owners. No affiliation is expressed or implied herein.

http://www.cvacsystems.com

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