Roller Compaction Process Optimization Using At-Line Particle Characterization

METTLER TOLEDO recently announced that a free webinar, “Roller Compactions Process Optimization Using At-Line Particle Characterization”, will be presented on December 2, 2009. In this webinar, the application of in situ particle characterization is demonstrated to map the design space and optimize a series of roller compaction runs while varying raw materials, flow rates, and roller compaction forces.

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Columbia, MD (PRWEB) November 20, 2009

As presented at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting2009, the application of in situ particle characterization is demonstrated to map the design space and optimize a series of roller compaction runs while varying raw materials, flow rates, and roller compaction forces during the free Roller Compactions Process Optimization Using At-Line Particle Characterization webinar.

In situ particle characterization allows formulators or engineers to detect process upsets such as segregation and directly link process control parameters to the particle distribution. This enables formulators to ensure consistent product performance. By designing a robust roller compaction process, formulators and engineers can ensure consistent downstream processing from dry granulation through tablet compression.

One goal of roller compaction is to improve compressibility and yield repeatable tablet dissolution and content uniformity. To ensure downstream process and product consistency, a successful roller compaction process establishes a continuous flow with a consistent particle size distribution. However, inconsistencies often occur during dry granulation scale-up due to changing raw materials or process dynamics such as segregation, compaction force, and flow properties.

After purchasing Lasentec® in 2001, METTLER TOLEDO has become the world leader for inline particle/droplet size, shape, and count characterization.

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