Promega - TOP srl Agreement Enables Live Animal Imaging for Cancer Studies

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Promega and TOP srl have combined their industry leading technologies to provide the most sensitive tools for monitoring apoptosis in live mammals, an important biomarker in cancer studies.

Promega Corporation

Promega and TOP srl have combined their industry leading technologies to provide the most sensitive tools for monitoring apoptosis in live mammals, an important biomarker in cancer studies. Under the agreement, the two companies are promoting the VivoGlo™ Caspase 3/7 Substrate for use with transgenic repTOP™ reporter mice. The tools allow the direct visualization and quantification of apoptosis non-invasively in live mice.

The study of apoptosis has generated much insight into the mechanisms of action of cancer over the past 20 years but nearly all studies to date have been performed in cells in culture and not in a more biologically relevant animal model such as mice.

TOP srl has developed a proprietary technology enabling the construction of transgenic animals in which the expression of imaging biomarkers is ubiquitous, tightly regulated, and constant among individual animals. Under the agreement, the transgenic repTOP reporter mice will contain an improved luciferase luc2 gene from Promega. It is now possible to study apoptotic processes in the whole live animal with these reporter mice with the same sensitivity and ease as in cell culture models, exploring physiology and pharmacological effects both spatially in different tissues and temporally. “We are pleased to be collaborating with Promega on the use of our transgenic mice with the VivoGlo Caspase 3/7 Substrate for studying apoptosis in vivo. The synergy of the two technologies is going to dramatically improve preclinical research for instance in oncology” said Paolo Ciana, PhD, Vice-President at TOP srl.

About Promega
Promega Corporation is a leader in providing innovative solutions and technical support to the life sciences industry. The company’s 2,000 products enable scientists worldwide to advance their knowledge in genomics, proteomics, cellular analysis, molecular diagnostics and human identification. Founded in 1978, the company is headquartered in Madison, WI, USA with branches in 14 countries and over 50 global distributors. For more information about Promega, visit http://www.promega.com.

About TOP srl
TOP srl is a leading company in the production of transgenic reporter mice for the application of in vivo imaging to drug discovery and development, basic research, and toxicology. TOP srl was founded in 2006 by Prof. Adriana Maggi and Dr. Paolo Ciana, of the University of Milan, is backed by the Next Fund of Finlombarda Gestioni SGR, and is based in Lodi, in Northern Italy. For more information, please visit the company’s website at http://www.top-mice.com

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Penny Patterson

Fabio Spreafico, Ph.D., MBA
TOP srl
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