New Deposition Data Available on The NasoNeb Nasal Nebulizer

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Two studies presented at the American Rhinologic Society (ARS) meeting demonstrated the deposition pattern of the aerosol generated by the NasoNeb system in both pre- and post-surgical subjects. The conclusion of one of the studies suggested that the NasoNeb system may be a better choice for delivering a high concentration of medication in a low volume of saline when compared to the traditional sinus rinse bottle. Both devices are used for treating chronic sinus infections and the NasoNeb may offer a better solution to the 30 million chronic sinusitis sufferers.

NasoNeb Device

"This event was particularly exciting as we observed study after study supporting the use of topical medications for sinus infections."

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ASL Pharmacy® (Camarillo, CA) participated in the Annual Meeting of the American Rhinologic Society (ARS) and the Annual Meeting of the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNSF) from September 25-29 in Boston, MA. In their commercial exhibit, ASL Pharmacy featured the NasoNeb™ Nasal Nebulizer, the sino-nasal drug delivery solution, manufactured by MedInvent, LLC (White Bear Lake, MN).

Two studies (1,2) presented at the ARS meeting demonstrated the deposition pattern of the aerosol generated by the NasoNeb system in both pre- and post-surgical subjects. In each case, the authors reported that the NasoNeb system deposits aerosol throughout the sino-nasal region, with one or the other reporting deposition in the anterior nasal cavity, olfactory cleft, middle meatus, sphenoethmoid recess, maxillary sinus, ethmoid cavity, sphenoid sinus, frontal sinus and the post-surgical frontal neo-ostium.

The conclusions of one of the studies suggested that the NasoNeb system may be a better choice for delivering a high concentration of medication in a low fluid volume (10 ml) when compared with traditional sinus rinse bottles, which typically use 100ml-240ml of saline to deliver the same dose of medication. Medication (2ml) mixed in a sinus rinse bottle with 100ml or more of saline will be diluted by over 5000%. The same amount of medication in the NasoNeb will only be diluted by 500%.

Another characteristic of sinus saline squeeze bottles is medication waste. With the squeeze bottle approach, approximately 97% of the diluted medicated saline goes down the drain. (3) The vast majority of the 10 ml delivered via the NasoNeb Nasal Nebulizer remains in the sino-nasal cavity until the body clears it naturally.

"This event was particularly exciting for ASL Pharmacy as we observed study after study supporting the use of topical medications for chronic sinus infections and related conditions. We anticipate that these two new studies demonstrating the deposition pattern of the NasoNeb system may provide the evidence-base necessary for physicians who were waiting for such data before prescribing the NasoNeb system for their patients." states ASL Pharmacy co-founder, Cal Tarrant.

Some additional features of the NasoNeb system are the ability to aerosolize medications that were difficult or impossible to nebulize with previous nasal devices. In addition, the particle sizes produced by the NasoNeb are designed to be large enough to be filtered by the nose before the aerosol reaches the oropharynx, so that the medication is not available for inhalation to the lungs.

In summary, the NasoNeb™ Nasal Nebulizer features: 1) a high concentration of medication, 2) a low volume of saline, 3) large particles that are filtered by the nose to reduce lung deposition, 4) high drug retention, and 5) minimal medication waste.

For more information about new study data on topical medications for the sinuses, please visit our website. You may view a short 3-min. NasoNeb Nasal Nebulizer demonstration at 3-min. demo

Reference Studies:

1) A Comparative Study of the Distribution of Normal Saline Delivered by Large Particle Nebulizer vs. Large Volume/Low Pressure Squeeze Bottle - Yuri M. Gelfand, MD; Samer Fakhri, MD; Amber Luong, MD, PhD; Seth J. Isaacs, MD & Martin J. Citardi, MD

2) Prospective Evaluation of a Novel Powered Nasal Irrigator Device in the Post-FESS Cadaver Model - R. Peter Manes, MD & Pete S. Batra, MD

3) Fluid Residuals and Drug Exposure in Nasal Irrigation - R.J. Harvey, MD; N. Debnath, MD; A. Srubiski, MD; B. Bleier, MD & R.J. Schlosser, MD

About ASL Pharmacy:

ASL Pharmacy is a pharmacy focused on serving the otolaryngologist-surgeon and the allergist in the treatment of sinus disorders (like chronic sinusitis) by providing custom formulated medications tailored to the patient's unique diagnosis. ASL Pharmacy dispenses the NasoNeb Nasal Nebulizer by prescription of the physician.

Aerosol Science®, ASL Pharmacy®, the ASL logo including the flask and the ASL type treatment are all registered trademarks of Aerosol Science® Laboratories, Inc. ©2010 All rights reserved.

MedInvent and NasoNeb are trademarks of MedInvent, LLC

For more information contact: Cal Tarrant at 805-482-5555 x300.

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CAL TARRANT
ASL PHARMACY
805-482-5555 ext. 300
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