A Recent Study Points to Specific Nutrients For Lowering the Risk of Premature Biological Aging, as well as, Age-Related Disease, Says Nutri-Med Logic Corp.

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Expanding on this recent study, Nutri-Med Logic says, while previous studies had linked biological premature aging, or age-associated diseases to a hyperactive / dysregulated immune system, and a DNA process called methylation, this recent study is linking biological premature aging, hyperactive immune system and DNA methylation to deficiency of specific nutrients.

Nutri-Med Logic Corp: A recently published study in the Journal of Nutritional Biochemistry states that the length of an indicator of biological aging (the extreme ends of the DNA) is associated with inflammation, oxidative stress and DNA methylation, all of which are influenced by certain specific nutrients.

The indicator of normal or premature biological aging is the end extremes of DNA, it is called telomeres, as a manner of speak a blank space that its end-point is the beginning of the genes sequence. Every time cells divide (mother cells producing daughter cells), the process cuts a very small portion of this blank region until it reaches a point that cutting a portion would result in cutting a portion of the genes and that means the end the cellular life. Abnormal or accelerated cellular division would result in premature biological aging or the demise of those cells.

As to inflammation and premature biological aging, inflammation is an immune mechanism, a call for cells to divide in order to form a larger population of immune cells. Every time cells divide the new cells would have a shorter life (shorter telomeres), which is a normal biological process.

However, if inflammation does not subside then the cell division repeats, unnecessarily, resulting every time in a shorter telomeres or, in another word, premature biological aging.

Nutrients have the ability to enhance or slowdown the inflammatory processes, more specifically two polyunsaturated fatty acids: Omega-6 and Omega-3, both of which are transported to the body through diet.

Omega-6 produces metabolites for sole purpose of enhancing and sustaining inflammation. Omega-3 produces metabolites called Resolvins in order to resolve the inflammation (Resolvin-E and Resolvin-D) to dampen the unnecessary cell division via inflammation; thus helping to normalize the biological cellular aging.

As the matter of fact, studies have established a way to control the master switch of inflammation (NF-kB) is through suitable dietary ratio of Omega-3/Omega-6. (1)

As to oxidative stress and premature biological aging, oxidative stress denotes too much of certain molecules that are produced through normal cellular breathing (Reactive Oxygen Species). Normally, the body eliminates excess Reactive Oxygen Species (ROS) through biological processes (Reduction) and utilizes the remaining to eliminates bacteria, fungi and parasites. (2)

The body eliminates the excess ROS, mainly, through an internal anti-oxidant called glutathione. (3)

However, the production of glutathione decreases by age and that results in excess ROS, which causes oxidative stress. Glutathione is found in food but its levels in the body does not increase, substantially, neither through food nor through glutathione supplementation. In 1996 a Professor of Molecular Biology at University of Berkley, Ca., discovered that an anti-oxidant by the name of R-Alpha Lipoic increases the glutathione levels in the body. R-Alpha Lipoic is made by the body but in conjunction with the metabolism of glucose (sugar). (4)

As to DNA Methylation and premature biological aging, lack of a nutrient called methyl, required for DNA, has been associated with shorter Telomeres or premature biological aging. (5,6)

The first experimental evidence of the age-dependent loss of genomic methylation was provided by G.D. Berdishev in 1967. Comparison of DNA isolated from tissues of embryos and newborn animals and as they aged (Ontogenesis) showed a gradual decrease of methylation upon aging.

Hypomethylation (low methyl availability) of the DNA results in imperfect maintenance of genome (genes) integrity, as the status of DNA methylation is balanced in mature cells but with age this balance is strongly shifted in favor of DNA demethylation (low methyl availability), thus causing a premature cellular death and/or cellular aging. (7)

Methyl is supplied through nutrients such as vitamins B6, B12, B9 (folic acid) and choline; the difference being that vitamins B6, B9 and B12 donate only one methyl group, whereas choline donates three (3) methyl groups.

PPC (Poly-Enyl-PhosphatidylCHOLINE) is an extract of soy, a natural and pure source of choline, a triple methyl provider.

In conclusion, Nutri-Med Logic Corp agrees with the recent study published in The Journal of Nutritional Biochemistry, associating lack of certain nutrients to premature biological aging, but adds that the most ideal nutrients would be those stated above, each carrying at least 40 years of scientific research.

Nutri-Med Logic Corp (http://www.nutrimedlogic.com) is a producer of dietary supplements such as:

A Concentrated and Balanced Omega-3 having the same concentration of EPA and DHA, 50% 50%. DHA of Omega-3 helps in resolving the inflammation in brain, nervous system and helps to moderate stress. EPA of Omega-3 helps in resolving the inflammation in the cardiovascular system;

R-Alpha Lipoic Acid, a potent anti-oxidant for combating oxidative stress. R-Alpha lipoic is made and known by the human body;

Poly-Enyl-Phosphatidylcholine, an essential phospholipid and an efficient source of dietary methyl.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements, herein, have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the supplements stated above; nor equate their supplementation to prevention, treatment or cure.

1. Biochemical Biophysical Research. 1996 Dec 13;229(2):643-7.
2. Arch Immunol Ther Exp (Warsz). 2011 Oct 5
3. Free Radic. Biol. Med. 30 (11): 1191–212 Glutathione
4. Biofactors. 1997;6(3):321-38
5. Oxford Journals, 2008 Volume17, Issue 18, Pp. 2776-2789
6. J. Nutr. July 2009 vol. 139no. 7 1273-1278
7. Epigenetics of Aging, DOI 10.1007/978-1-4419-0639-7_2,


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H.R. Zadeh
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