A New Cross-Species Study Points to Chronic Inflammation As An Impediment To Anti-Cancer Treatment, Say Nutri-Med Logic Corp.

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Expanding on this newly published study, Nutri-Med Logic Corp says that while clinical inflammation has a tumor restraining role, chronic inflammation not only opposes anti-cancer treatments, but it also permits cancer cells to escape repair or destruction.

Nutri-Med Logic Corp: Inflammation vs. Inflammation.

According to newly published study, the enhanced activity of a protein inside all cells, called nuclear factor-κappa B (NF-κB), causes resistance to chemotherapy. However, overwhelming number of studies have concluded that the same protein (NF-kB), at normal levels, confers tumor suppressing properties.

NF-kB is the master switch of inflammation in the body. Inflammation is an immune mechanism, as the matter of fact without inflammation there would be no immune activity. While clinical (acute) inflammation protects the body, even against formation of cancer cells, but the chronic (excessive) inflammation not only promotes cancer but also many degenerative diseases.

A cancer cell is any cell that its genetic formula has changed and, additionally, it has gained the ability to divide (proliferate) at a much faster rate than normal cells. Cancer cells do not follow the system, but retain the same knowledge of survival (genetic information) as the normal cells in the body and, thus, capable of manipulating the system for their survival and the survival of its offspring (daughter cancerous cells).

If successful in multiplying, they form a cluster and having the knowledge of the genetic formula, they cause formation of blood vessels (Angiogenesis) inside the cluster and thus form a tumor; an organ that was not put in place by design rather by defect. If the tumor could not be destroyed then the cancer cells will enter blood or lymph system and colonize (metastasis) and the cancer becomes terminal.

The human body has many checkpoints to insure that when a cell divides, the daughter cell has a correct genetic formula and that it will follow the system. Amongst such checkpoints, two proteins stand out by themselves: p53 and PTEN, which are made by genes of the same names. These two genes are also called Tumor suppressor genes and not withstanding many other factors (i.e. histone deacetylation, virus or gene deletions, etc.), chronic inflammation inactivates p53 and redox imbalance (oxidative stress) inactivates PTEN.

PTEN and P53 slow down the division of defective cells so that repair (Base Excision) would be done. If repairs cannot be done then an instruction for apoptosis (self-destruction) is given. If apoptosis fails then it would be unlikely for the immune system to stop the multiplication of cancer cells, as they divide at rate much faster than immune system could eliminate.

The cancer cells use the excessive reactive oxygen species (Redox Imbalance) to deal with PTEN and utilize chronic inflammation, via over-activation of NF-kB, to trigger an anti-apoptotic mechanism to sustain their survival and multiply, since the hyperactivity of NF-kB blocks (inhibits) the activation of p53.

Down-regulation (lowering the activity) of NF-kB is required for the p53 to instruct apoptosis, or in another word, instructions for self-destruction of unrepairable defective cell(s).

Since the activation of p53 would result in repairs or apoptosis (auto-destruction), then the inactivation of p53 equates to bypassing one of the most important checkpoints and the subsequent survival of defective cell(s). (2,3)

While, at the normal level (homeostatic), both reactive oxygen species and inflammation are assets to the immune system but their excessive levels are liabilities.

Nutrients have the ability to enhance or slowdown the inflammatory processes more specifically two polyunsaturated fatty acids: Omega-6 and Omega-3, both of which are transported to the body through diet.

Omega-6 produces metabolites for sole purpose of enhancing and sustaining inflammation. Omega-3 produces metabolites to Resolvin resolve the inflammation in the body (Resolvin-E and Resolvin-D), which help in moderating the inflammation.

As the matter of fact, studies have established a way to moderate NF-kB is through suitable dietary ratio of Omega-3/Omega-6. (1)

Needless to say that oxidative stress could also be moderated via anti-oxidant food.

While it would be very imprudent to state that nutrients could prevent the formation of cancer or stop its progression but, without a doubt, any nutrient or food that could interfere with the mechanism that cancer cells utilize, to survive and/or multiply, do matter. Anti-inflammatory and anti-oxidant nutrients help to moderate inflammation and oxidative stress, thus are very important.

In conclusion, Nutri-Med Logic Corp agrees with the this recent study but adds that not only chronic inflammation but also oxidative stress play a key role in pathogenesis and progression of cancer.

Nutri-Med Logic Corp (http://www.nutrimedlogic.com) is a producer of dietary supplements such as:

A Concentrated and Balanced Omega-3 having the same concentration of EPA and DHA, 50% 50%. DHA of Omega-3 is very beneficial for moderating inflammation in brain, nervous system and helps to moderate stress. EPA of Omega-3 is very beneficial in moderating the inflammation in the cardiovascular system.

R-Alpha Lipoic Acid, a potent anti-oxidant food for combating oxidative stress. R-Alpha lipoic is made and known by the human body;

Poly-Enyl-Phosphatidylcholine, an ideal dietary supplement for liver and intestine.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements, herein, have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the supplements stated above; nor equate their supplementation to prevention, treatment or cure.

1. Biochemical Biophysical Research. 1996 Dec 13;229(2):643-7.
2. EMBO J. 2003 October 15; 22(20): 5501–5510.
3. Biochemical pharmacology 72 (2006)1605–162

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H.R. Zadeh
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