A New Study Links Diet-Induced Obesity to Male Infertility, Says Nutri-Med Logic Corp.

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Expanding on this newly published study, Nutri-Med Logic Corp says until now obesity had been classified only as an inflammatory condition. However, this new study, linking diet-induced obesity to male infertility, brings to surface a long overlooked aspect of obesity: Redox imbalance.

Nutri-Med Logic Corp: A new study has pointed to oxidative stress as a cause of male infertility in diet-induced obesity. The study states that animals fed with a high fat diet had lower testosterone levels, resulting in a lower sperm count or, in other words, suggesting infertility.

Oxidative stress denotes too much of certain molecules that are produced through normal cellular breathing (Reactive Oxygen Species). Normally, the body eliminates excess Reactive Oxygen Species (ROS) through biological processes (Reduction) and utilizes the remaining to eliminate bacteria, fungi and parasites. (1)

The body eliminates the excess ROS, mainly, through an internal anti-oxidant called glutathione.(2) However, the production of glutathione decreases by age and that results in excess ROS, which is oxidative stress.

The relationship between glutathione, testosterone and oxidative stress has been studied and established, independently.

First, in animal studies, bilateral castration has resulted in lipid peroxidation (production of free radicals) and a reduced glutathione levels in both liver and kidney. Testosterone administration reduced lipid peroxidation in the liver of castrated rats; however, reduced glutathione status was not restored: confirming that absent of glutathione, testosterone would be used as an internal anti-oxidant but increasing the testosterone levels does not result in an increase of glutathione levels. (3)

Additionally, testosterone deficiency has shown to induce oxidative stress and that testosterone therapy was able to suppress oxidative stress, confirmation that testosterone is utilized as an internal anti-oxidant. (4)

One key change in adipose (fat) tissue during obesity is an increase in the infiltration of a particular class of immune cells (macrophages) and the subsequent production of pro-inflammatory agents, ultimately leading to increased oxidative stress (accumulation of reactive oxygen species), which increases the internal requirement for anti-oxidants.

While low fat diet and exercise would be the ideal scenario, but increasing glutathione levels would, at least, maintain better testosterone levels, as it relates to fat accumulation and its subsequent oxidative stress.

The process of neutralizing Reactive Oxygen via an anti-oxidant is called a Reduction process and obviously their production is through Oxidation processes. Redox is short for Reduction / Oxidation processes.

Glutathione is the major Redox buffer in the human body. (5)

Glutathione is found in food but its levels in the body do not increase, substantially, neither through food nor through glutathione supplementation. In 1996 a Professor of Molecular Biology at University of Berkley, Ca., discovered that an anti-oxidant by the name of R-Alpha Lipoic increases the glutathione levels in the body. R-Alpha Lipoic is made by the body but in conjunction with the metabolism of glucose (sugar). (6)

In conclusion, Nutri-Med Logic Corp agrees with this recent study and adds that while diet and exercise is the best manner to reduce corporal fat, but since glutathione decreases the need for testosterone (as an anti-oxidant), R-Alpha Lipoic increases the internal levels of glutathione, then supplementation of R-Alpha Lipoic should be included for obesity diets.

Nutri-Med Logic Corp (http://www.nutrimedlogic.com) is a producer of dietary supplements such as:

A Concentrated and Balanced Omega-3 having the same concentration of EPA and DHA, 50% 50%. DHA of Omega-3 is very beneficial for moderating inflammation in brain, nervous system and helps to moderate stress. EPA of Omega-3 is very beneficial in moderating the inflammation in the cardiovascular system.

R-Alpha Lipoic Acid, a potent anti-oxidant food for combating oxidative stress. R-Alpha lipoic is made and known by the human body;

Poly-Enyl-Phosphatidylcholine, an ideal dietary supplement for liver and intestine.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements, herein, have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the supplements stated above; nor equate their supplementation to prevention, treatment or cure.
1. Arch Immunol Ther Exp (Warsz). 2011 Oct 5.
2. Free Radic. Biol. Med. 30 (11): 1191-212.
3. Indian J Exp Biol. 2008 Aug;46(8):568-72.
4. Molecular Medicine Reports. Nov/Dec. 2011, Vol.4, No.6
5. American Journal of Respiratory Cell and Molecular Biology. Vol. 37, pp. 322-329, 2007
6. Biofactors. 1997;6(3):321-38

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H.R. Zadeh
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