Harvard Medical School And Three Other Institutes Have Presented New Findings, Implicating Immune System as a Cause in Cardiovascular Diseases, Says Nutri-Med Logic Corp

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Responding to this new study, Nutri-Med Logic says, The Harvard Medical School together with three other prestigious institutes have identified certain cellular activators (receptors) on the endothelial (blood vessels) cells, which activate bone-removing cells. The study correctly blames these receptors and a dysregulated immune system as a contributing factor in the cardiovascular diseases (atherosclerosis). However, by the virtue of the same receptors, a dysregulated immune system is a contributing factor to Osteoporosis, as well.

Nutri-Med Logic Corp: A new study by Harvard Medical School and three other prestigious institutes “Harvard Study”, published in the magazine of Endocrinology, states that the damage from oxidation of LDL (low-density proteins responsible for carrying cholesterol) is due to the activation of certain receptors, previously believed to be, additionally, activated only by certain immune cells (T-cells).

These specific receptors are called osteoclast-associated receptor (OSCAR). OSCAR causes differentiation (formation) of a cell line called Osteoclast (bone removing) cells, from immune cells. Their normal activation results in bone-remodeling and unnecessary activation results in bone diseases. In the normal bone remodeling process, after the bone-making cells (Osteoblasts) finish their task, they call the bone removing cells (Osteoclasts) via inflammatory signals (IL-6), to remove the old bone tissue, which is a normal biological process.

However, the same inflammation, if not resolved, will cause an over-activity of the bone-removing cells, thus reducing the bone density (osteoporosis). The relationship between dysregulated immune (inflammation) and osteoporosis has been well established.

However, this new finding links the over-activation of bone-removing cells to atherosclerosis, a cardiovascular disease.

In 2005, The American Society for Biochemistry and Molecular Biology reported that factors such as T-Cells (immune cells) do activate the bone-removing cells, independent of the bone remodeling process, via inflammatory signals (TNF), thus reducing the bone density unnecessarily. The Journal of Biological Chemistry, Vol. 280, No. 42, pp. 35209–35216, 11-21-2005

The American Society for Biochemistry and Molecular Biology stated that the activation of a protein (messenger), called Nuclear Factor Activated T-Cell c1 (NFAT c1), through the inflammatory signal of TNF caused the unnecessary formation of the bone-removing cells.

The Harvard Study suggests that LDL oxidation involves cell activation by osteoclast-associated receptor (OSCAR), normally activated by IL-6 or unnecessarily activated by T-Cells, and that the inhibition of NFAT c1 (activator of OSCAR) prevented the oxidation of low-density Lipoproteins (LDL) in the blood vessels.

The study concludes that the activation of OSCAR would produce results equal to atherosclerosis, suggesting that their inhibition would counter one important aspect of cardiovascular diseases.

The unnecessary induction of osteoclast-associated receptor (OSCAR), be it by LDL oxidation in blood vessels or through T-Cells (dysregulated immune system) not only would cause atherosclerosis but would ultimately result in lower bone density (promoting osteoporosis) through unnecessary activation of bone-removing cells.

The hyper-activation of OSCAR, whether resulting in atherosclerosis or osteoporosis, is due to an inflammatory signal called TNF, which its activation is only sustained through chronic inflammation.

Anti-inflammatory foods moderate the TNF through moderating the master switch of inflammation in the body. This master switch is called NF-kB and studies by the Department of Experimental Medicine and Oncology, University of Turin, Italy, suggests that a well behaved NF-KB could be achieved by means of a suitable dietary Omega-3. Biochemical Biophysical Research. 1996 Dec 13;229(2):643-7.

While it would be very imprudent to state that nutrients could prevent the formation of atherosclerosis or osteoporosis but, without a doubt, any nutrient or food that could help to moderate chronic inflammation is of great value.

In conclusion, Nutri-Med Logic Corp agrees with the study of the Harvard Study but adds that the unnecessary activation of the same receptors would also cause osteoporosis. Additionally, these receptors are directly linked to inflammation. Accordingly, there is a great need to investigate the role of clinical diets, containing an anti-inflammatory nutrients, as concurrent co-therapy.

Nutri-Med Logic Corp (http://www.nutrimedlogic.com) is a producer of dietary supplements such as:

A Concentrated and Balanced Omega-3, a potent anti-inflammatory nutrient.

R-alpha Lipoic, a potent anti-oxidant nutrient. R-Alpha Lipoic is made and known by the human body;

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements, herein, have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the supplements stated above; nor equate their supplementation to prevention, treatment or cure.

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H.R. Zadeh
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