BioDot Introduces an Automated, Non-contact Dropping Process to Generate Quality Metaphase Spreads in Preparation for Karyotyping & Fluorescence In Situ Hybridization

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The BioJet Plus™ Technology has been optimized to consistently generate metaphase spreads for the clinical laboratory setting. The miniaturization of the dropping volume from 10 µL to 0.5 µL has enabled high throughput capabilities in the area of FISH and karyotype analysis.  Multiple patients can now be applied to a single slide with an automated dispensing system, which will have a significant impact on throughput by improving technician output.

“BioDot has taken on a process that has long been viewed as an 'art,' and now provides an automated solution," says Tom Tisone, President of BioDot.

Use of cells for rapid analysis of chromosomal analysis and genomic diagnostics continues to expand and increase in clinical and research applications. Both direct interphase analysis using FISH and analysis of chromosomes through karyotyping have proven to be successful in providing relevant chromosomal information. With the expansion of these analytical techniques, increased throughput and decreased cost of sample preparation and processing have become critical and important factors.
 
The BioDot automation and dispensing technology have been used to miniaturize sample volumes, enabling sample and probe multiplexing.  This results in reduced costs, increased sample throughput, and improved test accuracy.
 
The BioDot technology can be used for both spotting of cells or metaphase chromosome preparations in nanoliter volumes for FISH and microscopic analysis. After spotting of cells for chromosome preparations, the BioDot technology can also be used to spot probe solutions onto samples in reduced volumes, saving on reagent usage and enabling multiplexing of samples and probes.
 
The BioDot BioJet Plus™ dispensing technology has been used to automate the slide dropping process for fluorescent in situ hybridization (FISH). In addition to developing an automated workstation for the application of patient cells to glass microscope slides, the dispense method is capable of jetting droplets as low as 10 nL in volume. This reduction in dispense volume now makes it possible to apply more than one cell spot per slide; consequently, lab throughput may be further increased, as multiple patients can be applied to one slide.

About BioDot Inc.

BioDot is the leading supplier of system tools for the research, development and commercialization of diagnostic tests. Our mission is to enable, inspire and educate scientists to commercialize their R&D ideas through to manufactured product. Using its core competencies in low volume non-contact dispensing, cutting/slitting, lamination, and strip assembly, BioDot has developed a range of equipment for the research and development, and manufacture of rapid tests. 

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Barbara McIntosh, VP Sales & Marketing
BioDot
(949) 440-3685
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