New Study Suggests An Association Between Omega-3 Fatty Acids, Insulin Resistance and Metabolic Syndrome

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Responding to this newly published study, Nutri-Med Logic Corp states, while Insulin Resistance and Metabolic Syndrome do have a common underlying symptom, which could also be a common underlying cause, that being the inflammation, but the most predominant cause emanates from Redox Imbalance: a cause that not only results in the common symptom of “Inflammation” in Metabolic Syndrome and Insulin Resistance but also Obesity and Diabetes .

Nutri-Med Logic Corp: A New Study, Published in Molecular Nutrition and Food Research, which included 452 subjects with Metabolic Syndrome, concludes that amongst those subjects, the higher level of Omega-3 Fatty Acids was associated with lower levels of fasting insulin; in another word, lower insulin resistance.

According to this study, a gene called Insulin Receptor Substrate-2 interacts with mono or polyunsaturated fatty acids, thus resulting in different outcomes, as it relates to insulin resistance.

It is a known fact that Omega-3 fatty acids are anti-inflammatory nutrients, which their role in sub-clinical inflammation, a major pathogenesis factor in the development of metabolic syndrome, has been established, going back to nearly a decade ago. Nutr. Metab. Cardiovasc Dis. 2004 Oct;14(5):228-32.

Metabolic syndrome, an inflammatory condition, affects almost one third of the adult population and it is a preceding condition to diabetes and coronary heart disease.

It has also been well established that low-fat diet, carbohydrate restriction are instrumental in lowering specific markers (high triglycerides and insulin resistance), with low Carb. diet being the more effective diet for reducing the biomarkers of both inflammation and triglycerides.

The relationship between carbohydrates and inflammation emanates from the body’s inability to metabolize carbohydrates, in most part due to an imbalance in cellular redox state: mainly lower NAD and higher NADH, two co-enzymes with profound application and implication in the Citric Acid Cycle (final steps in conversion of carbohydrates to energy)

The redox imbalance (low NAD reserves) causes conversion of glucose to palmitate, instead of ATP (Energy). Prolonged exposure to high levels of palmitate causes production of inflammatory agents such as TNF, which inhibits the activation of GLUT-4 (The Glucose Transporter Molecule) resulting in insulin resistance.

The effectiveness of low carb. diet for those with metabolic syndrome, is the prima facia evidence that the inflammation in such disease-state is more of a Symptom rather than a Cause. The most predominate Cause in metabolic syndrome would be the redox imbalance, a key contributing factor in the cell’s inability for converting glucose to energy but instead to fat (palmitate), thus, resulting in inflammation and the subsequent insulin resistance.

Nutrients such as R-Alpha Lipoic Acid have the inherent ability to change the ratio of NAD/NADH to the favor of NAD and thus confront a predominant Cause of metabolic syndrome and insulin resistance.

The role of R-Alpha Lipoic Acid, in diabetes, has been well documented and established, most noteworthy having received an approval, as a co-treatment in Diabetic Polyneuropathy, from the government of Germany more than 40 years ago.

In conclusion, Nutri-Med Logic Corp. agrees with this newly published study, to-wit an Omega-3 diet would be extremely beneficial for those with metabolic syndrome or insulin resistance.

However, a diet that would include a redox capable nutrients, such as R-Alpha Lipoic Acid, is equally important, if not more. Nutri-Med Logic Corp. adds that more attention needs to be dedicated to this predominate Cause (redox Imbalance) of metabolic syndrome, insulin resistance, diabetes, obesity and the role of nutrients such as R-Alpha Lipoic Acid for improving the redox imbalance.

Nutri-Med Logic Corp. is a producer of dietary supplements, including a Natural, Balanced and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3. Nutri-Med Logic Corp. is also a producer of a Pharmaceutical Grade R-Alpha Lipioic Acid, (also known as R-Lipoic Acid).

Nutri-Med Logic's products (http://www.nutrimedlogic.com) are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above have not been evaluated by The FDA and, thus, one should not relate the cause or diagnosis of any diseases, stated herein, to lack of the dietary supplements stated herein; nor equate their supplementation to prevention, treatment or cure.

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H.R. Zadeh
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