Andropause and Cardiovascular Disease: More Than an Epi-Phenomenon

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Collaborative scientific expert review article published in Journal of Geriatric Cardiology by age-management leader Cenegenics® Medical Institute and noted UCLA professor Dr. Ernst R. von Schwarz.

Cenegenics® Medical Institute, Global Leader in Age Management Medicine

Cenegenics Medical Institute: Headquarters for the global leader in age management medicine

An epi-phenomenon would suggest two conditions occur at the same time, but have nothing to do with each other. Our article is so named because it goes beyond that to the likely causal relationship of low androgen levels/aging and cardiovascular disease.

The expert scientific review, “Andropause and the development of cardiovascular disease: More than an epi-phenomenon,” was accepted for publication in the Journal of Geriatric Cardiology, announced Cenegenics® Medical Institute. The collaboration was performed with Dr. Ernst R. von Schwarz—professor of medicine at UCLA’s David Geffen School of Medicine. The article focuses on a concept hinged on the coexistence of two phenomena: declining male hormones and the rise of coronary artery disease.

The lay term “andropause” was created as a male counterpart to menopause. Medically, it refers to a hormone deficiency in combination with a decline of bodily function, such as physical capacity, body composition, libido, sexual function and increased risk of osteoporosis. All these conditions are linked to middle-aged symptoms—ones that go hand-in-hand with a reduction of testosterone, beginning in a man’s 40s and progressively declining from there. At the same time, early signs for metabolic de-arrangements, such as metabolic syndrome and vascular dysfunction, i.e. endothelial dysfunction, might occur among some men and develop into coronary artery disease, heart attacks and stroke.

“An epi-phenomenon would suggest two conditions occur at the same time, but have nothing to do with each other. Our article is so named because it goes beyond that. The hypothesis behind our scientific review is the likely causal relationship between low androgen levels and aging as well as its association with increased cardiovascular disease. We have seen that patients with coronary heart disease have reduced levels of testosterone and other sexual hormones, creating a viscous cycle. When we age, hormones decline and heart disease occurs—then the heart disease causes these sexual hormones to decline even further,” Schwarz said.

Whether replacement of testosterone in these men would be able to prevent the development or worsening of heart diseases, is currently unknown.

On the flip side, numerous studies on men and women with heart failure showed that if when treated with androgen therapy, they experience better functional capacity than those who aren’t undergoing the treatment.

Cenegenics says it stands committed to future collaborative studies to investigate the multi facets of the aging process. The global leader conducts research via its nonprofit Cenegenics Education and Research Foundation (CERF), which also offers a CME-accredited physician training/certification program in age management medicine.

For more information about Cenegenics’ highly regarded, CME-accredited Physician Training & Certification in Age Management Medicine, please visit their nonprofit Cenegenics Education and Research Foundation site.

For more information on Cenegenics, please visit their site, where you can register to read their online Healthy Aging Kit that includes the informative Guide to Healthy Aging, Executive Summary and media excerpts.

To schedule an interview, please contact Ann Castro, Cenegenics Director of Media Relations: 702.953.1588.

About Ernst R. von Schwarz, MD, PhD, FESC, FACC, FSCAI
Dr. Ernst R. von Schwarz is board certified in internal medicine by the American Board of Internal Medicine and in cardiology/cardiovascular diseases by the American Board of Internal Medicine. He is a noted professor of medicine at UCLA’s David Geffen School of Medicine. As a clinician and scientist, Schwarz has written more than 100 articles for peer-reviewed publications and has written 10 book chapters on cardiovascular medicine.

About Cenegenics
Cenegenics® Medical Institute, recognized leading authority in age management medicine, has two centers in Las Vegas, Nevada, as well as centers in Charleston, South Carolina; Boca Raton, Florida; Dallas, Texas; Arlington, Texas; Atlanta, Georgia; Chicago, Illinois; Beverly Hills, California; Philadelphia, Pennsylvania; Washington, DC; New York City, NY; Tulsa, OK; Jacksonville, FL; Atlantic City, NJ. Additional centers are scheduled to open in other major metropolitan areas in the near future. With an established presence in the medical community, Cenegenics uses a proactive approach based on solid science and comprehensive evaluation. Their established protocols have been recognized as the next generation of medical science, capturing global attention. Cenegenics offers CME-accredited physician training and certification opportunities in age management medicine via the nonprofit Cenegenics Education and Research Foundation (CERF). Headquartered in Las Vegas, Cenegenics serves more than 20,000 patients worldwide—2,000 are physicians and their families.


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