BellBrook Labs Launches Unique Microculture Slide for Probing Cell Function in a Native 3D Matrix

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The new iuvo™ 3D ICC Slide has precisely designed microchannels for the growth and analysis of cells in a biological 3D microenvironment. Based on the proprietary iuvo™ Microconduit Array platform, the slide overcomes a longstanding problem in cell biology by enabling immunocytochemistry in dense Extracellular Matrix (ECM) materials, such as Matrigel™. This capability will accelerate the adoption of more physiologically-relevant cellular models for cancer and other diseases.

The iuvo™ 3D ICC Slide enables immunostaining in 3D Extracellular Matrix (ECM)

BellBrook Labs today introduced the iuvo™ 3D ICC Slide, a microculture slide that enables immunocytochemistry in native biological Extracellular Matrices (ECMs), such as dense Matrigel™. The unique slide microchannels facilitate rapid diffusion of antibodies for immunocytochemical analysis of cells. This new approach overcomes the difficulties commonly associated with antibody immunostaining in dense matrices, such as uneven staining and detachment of matrix. As the need to investigate cells within a more “in vivo-like” environment grows, the demand for innovative, physiologically-relevant cellular assays has also increased. The novel iuvo™ 3D ICC Slide will address this demand by providing researchers a convenient, easy-to-use format for high-content, 3D immunocytochemistry analysis.

The new iuvo™ 3D ICC Slide provides even staining of both fixed and live cells within the ECM, while the ultra-low volume required for the microconduit design means far fewer cells are required than with current methods. This greatly reduces consumption of expensive matrices and precious primary cells. Designed for simplicity and ease-of-use, the iuvo™ 3D ICC Slide can be analyzed via microscopic imaging or High Content Instrumentation. Future plans include expansion of the slides to full plate format for lab automation compatibility and increased throughput, along with additional applications, such as cell migration and invasion.

About BellBrook Labs. BellBrook Labs, LLC develops detection reagents and microfluidic devices that accelerate the discovery of more effective therapies for cancer and other debilitating diseases. Transcreener® is a patented high throughput screening assay platform that was introduced in 2005 and is used to identify inhibitors for kinases and other types of protein drug targets. The iuvo™ Microconduit Array technology is a line of unique microscale devices for miniaturization and automation of advanced cell models that are more representative of human physiology. Visit BellBrook’s website for more information: http://www.bellbrooklabs.com.

Contact us at 866.313.7881 or info(at)bellbrooklabs(dot)com for more information.

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Robert Lowery
BellBrook Labs
(608) 443-2400
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