Stable isotope labeled peptides are playing an integral role in improving the effectiveness of drug research and development work.
Sunnyvale, CA (PRWEB) May 20, 2011
American Peptide Company, a leading innovator in peptide manufacturing and peptide-based services, is offering cost-effective, high-quality stable isotope labeled peptides for use as quantitative standards, and for structural analysis.
Applications in Quantification Standard:
The advent of stable isotopes have allowed the relative or even absolute quantification of proteins by mass spectrometric techniques based upon their well characterized increase in molecular mass compared to the native protein or peptide of interest. When combined with the reams of proteomics derived data that are continuously being generated, such quantification can be used in the detection and creation of innovative biomarkers. This approach can be particularly valuable when trying to compare and contrast the levels of specific proteins in two different biological states, like normal and pathophysiological cells or cells before and after drug treatment.
Applications in Structural Analysis:
As more and more peptides advance in clinical trials, both as therapeutic agents and as vaccines, NMR - a powerful technique for describing the structures, dynamics, and molecular interactions of biomolecules – can be used to measure their relaxation rates as they dissociate from their bound target. And since peptides often retain biological activity, they can stand in for whole proteins to simplify structural studies. NMR depends on stable isotopes; their uneven number of neutrons and protons gives them a nonzero spin that emits a detectable NMR absorption spectrum. Peptides labeled with 2H (spin of 1), 13C (spin 1/2), and 15N (spin 1/2) are all commonly used in NMR studies.
“Stable isotope labeled peptides are playing an integral role in improving the effectiveness of drug research and development work,” Firuz Shakoori said. “As it becomes increasingly imperative for scientists to produce fast, accurate results, American Peptide Company is pleased to support them with solutions that enhance the quality and cost-efficiency of their work.“
About American Peptide Company, Inc.
American Peptide Company (APC) is a leading manufacturer of peptides and peptide conjugates. The company offers comprehensive selections of pre-manufactured catalog peptides, custom synthesis, and GMP peptide active pharmaceutical ingredients (APIs). Our California based manufacturing facilities offer synthesis services under Non GMP (Sunnyvale, California) and cGMP (Vista, California) conditions. Our cGMP manufacturing is performed under strict adherence to FDA Regulations 21 CFR parts 210, 211 and ICH Guidance Q7A. Our Total Peptide Management services support clients in the drug development process from pre-clinical thru commercial stage. Our value added services include process development, scale up production, analytical/process validation, stability studies, CMC, DMF, and regulatory support.
APC is experienced in solid-phase and solution-phase peptide synthesis, as well as organic conjugations, proteins and PEGylation. As a wholly-owned subsidiary of ILS, Inc., a member of Otsuka group of Japan. APC has offices in the U.S. and representatives in Japan, South Korea, the UK, and China. APC remains dedicated to delivering high quality peptides to pharmaceutical and biotech companies worldwide. For more information, please visit http://www.americanpeptide.com.