Agile Sciences Awarded NIH Grant to Evaluate Anti-Biofilm Treatment for Chronic Wounds

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$300,000 NIH Phase I STTR Grant will support collaboration between Agile Sciences and the Center for Biofilm Engineering at Montana State University.

The National Institutes of Health (NIH) has awarded Agile Sciences a $300,000 Phase I STTR Grant for a project entitled “Development of Novel Anti-Biofilm Compounds for Treating Chronic Wounds”. Agile Sciences will conduct the study in collaboration with the Center for Biofilm Engineering (CBE) at Montana State University (MSU).

An estimated 1-2% of the population will suffer from persistent chronic wounds, and the costs associated with treating these wounds are estimated at $5 to $10 billion annually. The difficulty in treating chronic wound infections has been attributed to bacteria's ability to form biofilms, which are communities of microorganisms attached to a surface. Bacteria in the biofilm state are approximately 1000 times more resistant to antibiotics, and there are currently no reliable therapeutic strategies available for dispersing pre-formed biofilms.

In this one-year Phase I study, Agile Sciences will optimize their Agilyte™ biofilm-dispersal compounds to target biofilms formed by bacterial pathogens implicated in chronic wounds. These compounds will then be tested in established in vitro chronic wound biofilm models developed at the CBE.

Agile Sciences’ co-founder, Dr. Christian Melander, commented, “We are excited to evaluate the efficacy of our Agilyte™ technology using MSU’s state-of-the-art in vitro assays.”

CBE Director of Medical Research Projects, Dr. Garth James, stated, ”We look forward to testing Agile Sciences’ compounds using the models that we have developed at the CBE. Agile Sciences has been an Industrial Associate of the CBE for 2 years, and we welcome this opportunity to expand our interactions with the company.”

About Agile Sciences:
Agile Sciences is headquartered on North Carolina State University's Centennial Campus. The company was founded in 2007 by Professors Christian Melander and John Cavanagh of North Carolina State University (NCSU) to provide commercial solutions to those industries plagued by the effects of biofilms. The company's proprietary compounds are derived from the Agelas conifera sea sponge and have been shown to be effective in dispersing biofilms. For additional information, please visit:


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Keith Stoneback
Agile Sciences
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