Simmons Firm Investigates Type 2 Diabetes Drug Linked to Bladder Cancer

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Actos taken for a prolonged time period and at a high dosage has an increased risk of bladder cancer, FDA warns.

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In addition to the increased risk of bladder cancer, other Actos side effects include an increased risk of: congestive heart failure (CHF), rare but serious liver problems, and bone fractures.

Simmons Browder Gianaris Angelides & Barnerd LLC is currently investigating claims that Actos, a drug manufactured by Takeda Pharmaceuticals to treat type 2 diabetes, can increase the risk of developing bladder cancer.

Actos, FDA approved in 1999, is a drug that contains the active ingredient pioglitazone hydrochloride, a type of thiazolidinedione or glitazone. The drug works to reduce blood glucose levels by increasing the sensitivity of the liver, fat and muscle cells to insulin, a hormone that is produced by the pancreas which is either underprovided or absent in diabetes patients.

On June 15, 2011, the FDA informed the public through a drug safety communication that “use of the diabetes medication Actos (pioglitazone) for more than one year may be associated with an increased risk of bladder cancer.”

This FDA information is based on a review of data from a planned five-year interim analysis of an ongoing ten-year study. A similar study conducted in France has already led to the suspension of Actos in both France and Germany.

In addition to the increased risk of bladder cancer, FDA drug and safety warnings also indicate that other Actos side effects can include an increased risk of: congestive heart failure (CHF), rare but serious liver problems, and bone fractures.

“While the safety warnings on Actos will be updated, that is still too late for the many people who’ve taken Actos to treat type 2 diabetes and were unaware of its long-term effects,” said Trent Miracle, Simmons Firm Partner who is leading the investigation.

If you are currently taking Actos, discuss risks and benefits with your doctor. Do not stop taking any medication until you have discussed this information with your health care provider.

The Actos lawyers at the Simmons Law Firm are currently investigating claims against Actos. Learn more information from these Actos lawyers.

About Simmons Browder Gianaris Angelides & Barnerd LLC
The Simmons Firm is a leading law firm in pharmaceutical litigation. The Simmons firm has experience in litigating complex medical matters and has taken a leadership role in standing up for individuals who have been injured by dangerous or defective drugs. The firm has represented thousands of pharmaceutical clients and recovered more than $230 million in verdicts and settlements. Learn more at http://www.simmonspharmalaw.com.

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Mark Motley
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