A Recent Meta-Analysis Presents Surprising Finding Regarding A Specific Component of Omega-3 Fatty Acids and Attention Deficit and Hyperactivity Disorder (ADHD)

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A recent report by Yale School of Medicine, which involved review of PubMed randomized placebo-controlled trials of 699 children, regarding Omega-3 Fatty Acid supplementation and Attention Deficit Disorder (ADHD), makes a surprising recommendation as to the EPA component of Omega-3. Nutri-Med Logic Corp, agreeing in one part but disagreeing with another part, states that only the DHA component of Omega-3 could be is utilized in the brain and nervous system and, thus, the DHA component is as relevant as EPA component of Omega-3 Fatty Acids, if not more, unless the subjects in such studies, Reviewed by Yale, had other existing conditions.

Nutri-Med Logic Corp: A recent report by Yale School of Medicine, which involved the review of ten randomized placebo-controlled trials involving 699 children with Attention Deficit and Hyperactivity Disorder (ADHD), states that Eicosapentaenoic acid (EPA) component of Omega-3 fatty acids correlated with supplement efficacy.

The report further states that studies have demonstrated differences in Omega-3 fatty acid composition in plasma and in erythrocyte (red blood cells) membranes in ADHD patients compared with unaffected controls and, further, that Omega-3 fatty acids have anti-inflammatory properties and can alter central nervous system cell membrane fluidity and phospholipid composition.

While the report recommends the EPA component of Omega-3, but the EPA component of Omega-3 has no role in the cells' membranes of the nervous system (neuron) cells.
Neurons can only accept DHA component of Omega-3, which produces Resolvin series D. The function of Resolvin Series D is to resolve inflammation in the nervous system. According, the report is self-contradictory, in such context.

While studies have supported the “hypothesis” of a positive association between “EPA and a cognitive bias” in the red blood cells, but same has been only in context of expressing happiness and fear. At the same time many other exploratory analyses has revealed a positive association between levels of docosahexaenoic acid (DHA) and covert expressions of fear. Prost. Leukot Essent F.A. 2009 Feb-Mar;80(2-3):151-6

Additionally, Nutritional Physiology Research Centre, University of South Australia, Australia, investigated Associations between Omega-3 Fatty Acid and erythrocytes (red blood cells) and learning, behaviour in 75 children aged 7-12 with ADHD. Children with higher docosahexaenoic acid (DHA) had better word reading vocabulary, spelling and attention. Thirty-six per cent of the sample with learning difficulties had lower DHA than those without. Journal of Child Health Care. 2011 Dec;15(4):299-311

Moreover, the importance of DHA component of Omega-3 and ADHD was reported by us in our Press Release of October 1st, 2011, whereas children who received a diet averaging 500mg DHA on daily basis for 2 months, visual short-term memory and errors of commission (continuous performance) significantly improved in the DHA (Omega-3 diet) group. European Journal of Clinical Nutrition. 2004 Mar; 58(3):467-73

It is noteworthy to state that studies have suggested an increased rates of Attention Deficit Symptoms in children with inflammatory conditions such as asthma. Journal of Asthma. 2008 Sep;45(7):545-7.

Accordingly, children suffering from inflammatory conditions such as Asthma and ADHD could receive additional benefit from EPA component of Omega-3. However, to generalize a specific condition as a general recommendation it not what we believe Yale School of Medicine intended.

Whether EPA or DHA of Omega-3, It is a known fact that low levels of Omega-3 fatty acids have been linked to a range of behavioral and mood disorders, which includes ADHD.
In conclusion, Nutri-Med Logic Corp agrees with the Yale School of Medicine that Omega-3 Fatty Acids present a valuable benefit for children with Attention Deficit Disorder, but adds that both components of Omega-3 play an important role in such children. Nutri-Med Logic Corp adds that a plethora of studies support the position by Nutri-Med Logic Corp. relating to the DHA component of Omega-3.

Nutri-Med Logic Corp. is a producer of dietary supplements, including a Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3.

Nutri-Med Logic Corp. is also a producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietarty supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for about 50 years; producer of a Pharmaceutical Grade R-Alpha Lipioic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.


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H.R. Zadeh
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