New Double-Blind, Randomised, Controlled Trial Suggests That Supplementation of Omega-3 Resulted Only in Significant But Short-Term Weight Loss, in Obese Individuals

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A new study by The School of Biomedical Sciences and Pharmacy, The University of Newcastle, Australia, reports significant reduction in fat mass of the obese subjects, in the Omega-3 group, but only up to 14 weeks and that Omega-3 did not promote weight loss, thereafter. Expanding on this new study, Nutri-Med Logic Corp state that, while Obesity is also an inflammatory disease but the study incorporated an Omega-3 ratio much more favorable to the nervous system and a balanced ratio would yield long-term benefits, as well.

Nutri-Med Logic Corp: A new study published in British Journal of Nutrition, which incorporated 6 daily dosage of Omega-3, each consisting of 70mg EPA and 270mg DHA for 4 weeks, followed by 10 weeks of weight maintenance resulted in weight loss only up to the 14th week.

None-the-less, according to the study, further supplementation of Omega-3, past week 14, had no significant effect on weight loss or weight maintenance.

Omega-3 has two important fatty acids: EPA and DHA. The study incorporated a 4:1 ratio in favor of DHA.

The DHA fatty acids is mainly utilized for brain and nervous system, whereas the EPA fatty acids for outside of the nervous system.

The role of high DHA dosage in weight loss emanates from moderation of Cortisol. Stress, be it psychological or physiological, produces Cortisol, which causes fat to be deposited viscerally for men as well as hip area for woman. The visceral fat produces the hormone visfatin and the higher levels of visfatin has been correlated with higher fat mass in human.

Additionally visfatin, also known as Nampt, affects the cellular redox balance and, as consequence, increases the inflammation.

DHA fatty acids of Omega-3 moderate Corticotrophin-Releasing Hormone, which is the parent hormone to cortisol and lower chronic cortisol levels correlates to lesser visceral fat and visfatin.

The beneficial properties of DHA fatty acids of Omega-3 and Cortisol has been well established in the cases of depression and anxiety due to stress (cortisol). The same has held true here.

Obesity is also an inflammatory condition. The changes in inflammatory status of fat tissues, in obese individuals, represents a state of chronic low-level inflammation. PPAR Research. Volume 2007 (2007), Article ID 95974.

Studies have shown positive correlation between fat tissue mass and inflammatory agents such as tumor necrosis factor-alpha and acute phase proteins such as C-reactive protein in obese individuals. Biochem Soc Trans. 2005 Nov;33(Pt 5):1078-81.

EPA of Omega-3 fatty acids produce Resolvin Series E, which resolve the inflammation outside of the nervous system, including but not limited to moderating the production of tumor necrosis factor-alpha and C-reactive protein.

The combined but equal role of EPA and DHA is more evident by the Proxisome Proliferator-Activated Receptors (PPAR).

PPAR-alpha and PPAR-gamma not only play an important role in the liver and adipose tissues, respectively, but they are also found to breakdown the inflammatory eicosanoids in the inflammatory cells, which promote inflammation. The breakdown of inflammatory eicosanoids is done through induction of proxisomal Beta-Oxidation. Additionally, PPARs interfere (antagonize) the activation of other transcription factors such as NF-KB. Chinetti et al. 2001; Delerive et al. 2001.

NF-kB promotes and enhances the inflammation, including but not limited to tumor necrosis factor-alpha and C-reactive protein, both of which are implicated in Obesity.

Studies have suggested that a well behaved NF-KB could be achieved by means of a suitable dietary Omega-3. Biochemical Biophysical Research. 1996 Dec 13;229(2):643-7.

In conclusion, Nutri-Med Logic Corp agrees with this recent study that supplementation of Omega-3 would have a beneficial short-term benefits in Obesity but adds a balanced Omega-3 would also provide other long-term benefits.

Nutri-Med Logic Corp. is a producer of dietary supplements, including a Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3.

Nutri-Med Logic Corp. is also a producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietarty supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for about 50 years; producer of a Pharmaceutical Grade R-Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

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H.R. Zadeh
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