Studies Are Pointing to Oxidative Damage As a Significant Risk Factor in The Development And Progression of Diseases, Ranging From Arthritis to Alzheimer

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A newly published study, which entailed 10 years of research, is shedding a more deserving light to another important health risk factor: lack of antioxidant defense, which has been implicated in many diseases, ranging from Arthritis to Alzheimer. Going back to 1987, when the first study suggested a common factor (inflammation) in diseases ranging from Arthritis to Alzheimer, at least, 1459 other studies have followed, only investigating the role and association of inflammation in the development and progression of Alzheimer. Nutri-Med Logic Corp states that the lack of anti-oxidant defense in the development and progression of diseases is as important as the role of inflammation, if not more.

Nutri-Med Logic Corp: A newly published study, in Antioxidant and Redox Signaling Journal, implicates the imbalance between the anti-oxidant defense and free radicals as contributing factor in improper protein formation and would correlate with neurodegenerative diseases such as Alzheimer.

Free radicals are molecules that are not balanced and could be either oxygen or nitrogen centered and in order to balance themselves, they takeaway electrons from other molecules, causing an imbalance and, consequently, exerting damage to the human body.

Lack of cellular anti-oxidant defense causes an accumulation of the free radicals, thus, damaging cellular membranes, proteins and all the way up to the mitochondria.

Interestingly, in the same manner that inflammation was first suggested to be present and/or cause diseases ranging from Arthritis to Alzheimer, lack of anti-oxidant defense (redox imbalance) is following the same pathway. (1)

Arthritis and Rheumatism, an official monthly journal of the American College of Rheumatology, which involved a large-scale protein analysis in Rheumatoid Arthritis patients, also recently published a study implicating a cellular mechanism for the progression of Rheumatoid Arthritis. This mechanism is the cellular oxidation/reduction (Redox) pathways. Its dysregulation is proposed to advance Rheumatoid Arthritis and its regulation is being studied for the development of anti-cancer drugs. (2, 3)

These recent studies are targeting or implicating the Redox imbalance in diseases ranging from Rheumatoid Arthritis to Alzheimer, in the same manner that studies in the role of inflammation began and, later, became the focus of attention.

According to the study, in Antioxidant and Redox Signaling Journal, protein oxidation by free radicals may present physiological and pathological significance and, further, the modification of proteins through free radicals would correlate with diseases such as Alzheimer.

Interestingly, the study in Journal of Arthritis and Rheumatism, also reported that from screening 100 differential proteins, down-regulation of oxidation reduction-related proteins in Fibroblast-like synoviocytes (FLS) was found to be a predominant factor, which may contribute to the development and progression Rheumatoid Arthritis. (2)

Additionally, according to The Department of Internal Medicine of University of Miami, the cellular redox is regulated by three systems that counteract with free radicals . Two of the above systems are regulated by glutathione. Too much of free radicals causes oxidation of glutathione. (3)

in 1996, an anti-oxidant researcher at University of Berkeley, California, Dr. Packer, a professor of molecular and cell biology discovered that R-Alpha Lipoic Acid, a nutrient, increased the production of Glutathione.

R-Alpha Lipoic Acid (also known as R-Lipoic Acid) is a biologically significant (active) compound produced by human body and found in many foods. R-Alpha Lipoic Acid, not only increases the internal anti-oxidant “glutathione”, but also amongst its many other vital properties inactivates free radicals. (4)

In animal studies, R-Alpha Lipoic Acid has easily crossed the blood-brain barrier and reached peak levels in the cerebral cortex, spinal cord and peripheral nerves within 30 minutes of administration. (5)

R-Lipoic Acid is hydrophilic (liquid soluble) and lipophilic (fat soluble) and easily penetrates cell membranes and reaches high intracellular concentrations within 30 seconds of its administration. (6)

In conclusion agrees with these recent studies relating to redox imbalance and the development and progression of diseases such as Arthritis and Alzheimer but adds that an anti-oxidant of choice should be an anti-oxidant capable of reaching the entire body.

Nutri-Med Logic Corp. is a producer of dietary supplements, including a Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years.

Nutri-Med Logic Corp is also producer of a Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietarty supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for about 50 years.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above and/or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

1. Can J Physiol Pharmacol. 1987 Sep;65(9):1805-15.
2. Arthritis Rheum. 2011 Oct 17
3. Drugs. 2011 Jul 30;71(11):1385-96
4. Toxicology and Applied Pharmacology, Vol. 182, Issue 1, 1 July 2002, PPs 84-90.
5. Neurotoxicology 2001;22:577-592.
6. Archives of Biochemistry and Biophysics 1989;273:389-395.


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H.R. Zadeh
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