New Study Suggests Metabolic Homeostasis As A Novel Opportunity In The Treatment of Diseases Such As Diabetes

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A recently published study in the World Journal of Diabetes suggests that the body’s inability to clear free radicals leads to an imbalance in the body's homeostasis, which contributes to development of disease states such as diabetes, metabolic syndrome, cancer and even aging. Expanding on this new study, Nutri-Med Logic Corp states that while the study correctly states the consequences of redox imbalance and its implications, homeostatic imbalance is not limited to only redox imbalance and that there are, at least, three other key areas that affect the homeostasis, all of which highlight the role of proper nutrients in the daily diet.

Nutri-Med Logic Corp expands on a new study, published in the January Issue of the World Journal of Diabetes, which has targeted a gene (Nrf2), a central regulator of the cellular antioxidant defense, as a novel target for the treatment of Diabetes.

Nrf2 produces the most potent internal anti-oxidant, that being glutathione and while glutathione is found in food but studies have shown its concentration does not increase, significantly, through conventional food or its dietary supplementation.

Additionally, glutathione decreases by age and lack of glutathione shifts the body’s homeostasis toward oxidative stress, which according to this study, oxidative stress, may lead to the pathogenesis of diabetes, cardiovascular diseases, metabolic syndrome, aging and cancer.

Proper nutrients play an important role in enhancing or moderating the factors that shift the body’s homeostasis.

In 2004, a panel of U.S. and Canadian scientists recalculated the amounts of vitamins and minerals, based age and sex, and declared 30 vitamins and minerals as the raw materials that body requires “daily” but it cannot make in sufficient amounts: Essential Nutrients.

It is a fact that lack of these 30 essential nutrients plays an important part in the homeostasis of the body and some of those present important anti-oxidant properties. However, none of these 30 essential nutrients would increase the levels of glutathione, the most potent endogenous anti-oxidant, which recycles vitamin C and E, as well as re-energizing Co-Enzyme Q-10, an important anti-oxidant for the heart.

In 1996, Professor Lester Packer a senior anti-oxidant researcher and scientist at the University of California (Berkley) discovered that dietary supplementation of R-Alpha Lipoic Acid (also known as R-Lipoic Acid), increased the production, as well as the cellular concentration of glutathione. R-Alpha Lipoic, in its reduced form, is made by the human body, as a vital co-enzyme in the metabolism of glucose.

Stress and inflammation, also, play an equal but crucial role in shifting the body’s homeostasis and are implicated in diseases, ranging from degenerative, neurodegenerative, chronic, autoimmune to opportunistic and infectious diseases.

A cursory search of PubMed records reveals at least 200,000 related studies in the role of stress or inflammation and diseases, as well as, at least 2,100 related studies of Omega-3 fatty acids in inflammation and stress.

The primary mechanism for the resolution of the inflammation starts from the cellular membrane through the derivatives of the fatty acids of Omega-3. The membrane ratio of Omeg-3 dictates the intensity and the duration of inflammatory responses.

Diets lacking Omega-3 tilt the balance to the pro-inflammatory agents, thus throwing the body out of its homeostasis, as well.

The role of stress and homeostasis has been well studied and established. More importantly, the role of Omega-3 in moderating stress, specifically in the cases of depression and anxiety, has been even suggested by The National Institutes of Health.

The human body needs Omega-3 but cannot produce it. In the scientific community, Omega-3 is referred to as Essential Fatty Acids.

In conclusion, Nutri-Med Logic Corp agrees with this recent study and the consequences of a redox imbalance but adds that stress and inflammation, also, play a crucial role in the homeostasis of the human body. Nutri-Med Logic Corp adds that the foregoing clearly establishes the need for inclusion of an anti-oxidant and an anti-inflammatory nutrient in the daily diet.

Nutri-Med Logic Corp. is a producer of dietary supplements, including a Pharmaceutical Grade R-Alpha Lipoic Acid, the ideal daily anti-oxidant and the dietary supplement of choice for the Diabetics, in Germany for more than 40 years.

Nutri-Med Logic Corp is also producer of a Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietarty supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for about 50 years;

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

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H.R. Zadeh
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