Curiox Biosystems Introduces DropArray™, the Solution to Cell Loss

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New technology allows high content analysis of adherent or suspension cell systems using fewer cells and a fraction of the media and reagents that are traditionally used.

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DropArray™ the solution to cell loss

DropArray may well be the system I am looking for to screen large panels of cancer cell lines

DropArray gives scientists the freedom to run cellular assays as their research demands, and not based on the availability of cells or cost of reagents. Developed by Curiox Biosystems, an emerging leader in bioassay technology, DropArray is a patented* system for low-volume cell-based assays. It allows scientists to use a fraction of the cells, media and reagents they have traditionally used, and still acquire rich, high content data. Equally effective for adherent and suspension cells, DropArray eliminates evaporation, and is compatible with most automated plate handling and imaging equipment.

DropArray Microplates support assays including those requiring long-term incubation and multiple washing steps, even when using suspension or weakly adherent cells. “I was very impressed that my PBMCs were retained so well on the DropArray plates after substantial washes and treatment,” said Justin D. Boyd, Ph.D., at the Harvard Medical School Laboratory. DropArray is perfect for in vitro toxicity assays, and high content screening using scarce or expensive cells, like hepatocytes, lymphocytes and stem cells. Jean-Bernard Lazaro, Ph.D. at the Dana-Farber Cancer Institute added, “DropArray may well be the system I am looking for to screen large panels of cancer cell lines.”

Using standard liquid dispensing equipment, cell sample drops containing as few as 100 cells are deposited on to DropArray microplates. The cell samples bind to small hydrophilic spots in 96 or 384 array patterns on the flat, hydrophobic surface of the plate. DropArray Liquid Lid, an immiscible, gas permeable fluid, is used to cover and protect the samples, yet allows gas exchange. Established procedures for cell-based assays like plate washing and treatment with reagents and compounds may still be performed, but much less media and buffer are required.

The DropArray microplates are constructed of either polystyrene (PS) or cyclic olefin copolymer (COC), a rigid, optically clear polymer. The plate surface has a thin film coating of hydrophobic PTFE precisely perforated with a 96- or 384-array pattern forming hydrophilic spots. Surface treatments available for coating the hydrophilic areas include tissue culture, poly-d-lysine, or collagen. The plate dimensions meet ANSI/SBS standards for automation compatibility. DropArray plates are packaged sterile for shipping and supplied in bags of 10 items each. Accessories include DropArray Liquid Lid fluids, plate lids and removable grids. Starter kits are available.

Curiox recently introduced the LT210 (low throughput) and HT200 (high throughput) DropArray Washing Stations to automate the task of adding and changing media and buffers with a simple push of a button. Plates are positioned in the liquid-tight chamber of the system’s washing station, and an aqueous washing buffer is automatically applied. A gentle shaking motion washes the plates with a minimal loss of cells. Despite the low velocity washing action, plate processing time is comparable to traditional plate washers because the entire plate is treated at once.

For additional information, visit For questions or technical support, contact Curiox Biosystems in the US at 1-650-226-8420

About Curiox Biosystems
Curiox Biosystems develops and commercializes revolutionary cellular assay systems. Its first product, the DropArray™ platform is intended to accelerate the progress of basic research, drug discovery and diagnostics through the miniaturization and automation of bioassays. The company brings together an expertise in surface chemistry and engineering that has enabled it to become an emerging leader in the field of bioinstrumentation.

Curiox Biosystems was founded in 2008, when a research group, started by Dr. Namyong Kim, developed DropArray technology at the Agency for Science, Technology and Research, also known as A*STAR in Singapore.

Curiox Biosystems entered the US with the formation of Curiox Biosystems Inc. in San Carlos, CA on December 21st, 2010. Curiox prides itself on offering experienced and technically adept representation of its products. Customers can expect product demonstrations, application trials and comprehensive technical support. Curiox Biosystems has been recognized by a growing number of industry partners, institutions and associations, including the following:

2010 Asia Pacific Frost & Sullivan Technology Innovation Award in the field of BioAssays for In-vitro Diagnosis

• The BioSpectrum Asia Pacific Emerging Company of the Year Award for 2010

• Special Invitation to exhibit at Japan Analytical Instruments Manufacturers Association (JAIMA) by JETRO (Japan External Trade Organization)

• Selected under Singapore's Technology Enterprise Commercialization Development scheme of SPRING, to develop tabletop, DropArray-based near-the-patient ELISA instrument.

• Recognized and funded by the International Enterprise (IE), an agency under the Singapore Ministry of Trade and Industry under its Singapore's International Capability Program.

• DropArray was chosen as one among the eight emerging laboratory automation technologies recognized by the Innovation AveNEW program at the 2010 LabAutomation meeting.

At Curiox Biosystems, we provide brilliantly simple ideas to life sciences with the aim to accelerate the progress of basic research, drug discovery and diagnostics through the miniaturization and automation of bioassays. In the pursuit of assisting the biomedical research community, we’re pleased to share our expertise in surface chemistry and engineering and to make an impact on the world of science.

*Patented in Singapore, Japan and China, and patent-pending in the USA and the European Union.

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Namyong Kim

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