Studies Suggest That The Output of A Hormone With A Key Role in Energy Homeostasis And The Development Of Diabetes Type II Could be Improved Through Specific Diet

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A Newly published study, investigating the role of an anti-inflammatory hormone, which its decline has been associated with diabetes type II, obesity and cardiovascular diseases, suggests a specific diet for its functional improvement. Agreeing in part, Nutri-Med Logic Corp states that any proper diet that could increase the intake of anti-inflammatory and anti-oxidant nutrients would be fundamental in promoting good health, cardiovascular and diabetes included. However, as to the subject anti-inflammatory hormone of this new study, stress plays a more predominant role in its decline.

A newly published study suggests that the function of Adiponectin, an anti-inflammatory hormone, secreted by the fat tissue to increase the sensitivity of human cells to insulin, maintain and regulate energy homeostasis and proper lipid (fat) metabolism could also be improved through a Mediterranean Diet. Nutri-Med Logic Corp states that, as it relates to Adiponectin and its decline, stress is a more predominant cause of its decline, thus diets that tilt more toward nutrients capable of moderating both stress and inflammation would provide a more comprehensive result.

The role of adiponectin in regulating the metabolism of glucose and fat is fundamental. Additionally, elevated blood level of adiponectin has been associated with a reduced risk of heart attack. Conversely, low levels of adiponectin has been associated with higher risk of Obesity.

In 2010, Cleveland Clinic published the result of their study even suggesting a protective role, by adiponectin, form alcohol-induce liver injury. (1)

Plethora of studies have suggested high adiponectin levels deter metabolic and cardiovascular disease progression, through its anti-inflammatory properties.

This new study suggests a Mediterranean diet, as one of the management strategies to increase the adiponectin levels.

One of the most predominant factors in suppression of adiponectin is stress.

Stress, be it physiological or physiological, produces cortisol, which causes the inhibition of adiponectin needed to increase insulin sensitivity, increase fatty acids oxidation, reduce triglycerides and improve glucose metabolism. (2)

Glucocorticoid (the parent to cortisol) inhibition of adiponectin, in human, has been shown by both exogenous administrations to healthy subjects and endogenous cortisol hyper-production. (chronic inflammation and chronic stress).

Levels of adiponectin in obese patients and their obese controls have indicated a relationship between adiponectin and cortisol. (3)

In animal studies, the adiponectin was increased 2.7 fold through a diet rich in Omega-3 Fatty Acids. (4)

In addition, studies done by The U.S. National Institute on Alcohol Abuse and Alcoholism, U.S. National Institutes of Health, have shown that low Omega-3 DHA fatty Acids levels were correlated with the elevated levels of cortisol. Studies have shown that DHA intake could moderate cortisol levels in the humans. (5)

Accordingly, the only portion of the Mediterranean diet that would be effective, in moderating stress, is the fish portion, which provides Omega-3 to the human body.

While it is true that seeds and legumes have unsaturated fatty acids but that includes mono-unsaturated and the polyunsaturated fatty acids of Linoleic Acid (the precursor to Omega-6 fatty acids). Omega-6 is a competitor to Omega-3 and inhibits the full conversion of Alpha-Linolenic (DHA precursor) to Omega-3 DHA Fatty Acids.

In Europe, there is a dietary intake guideline for Omega-3 “as a dietary supplement” but none has been established in US. However, the US scientific body has recommended a daily intake range of 250mg to 500mg of Omega-3, in order to promote good health.

The Omega-3 DHA Fatty Acids intake from fish portion of the Mediterranean diet thoroughly depends on the amount, frequency and the type of the fish, whereas the intake of Omega-3 DHA fatty Acids, from its dietary supplementation, is a label fact.

In conclusion, Nutri-Med Logic Corp agrees with this recent study and beneficial role of a proper diet to increase adiponectin but adds since stress plays a key role in the decline of adiponectin, the direct supplementation of DHA Omega-3 Fatty acids should be added to any diet utilized for the management of adiponectin levels.

Nutri-Med Logic Corp is producer of dietary supplements, including the Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3.

Nutri-Med Logic Corp. is also a producer of Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietarty supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for about 50 years.

Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on the potential benefits of Omega-3 and What Is Omega-3 Good For.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

1. Hepatology. 2010 Apr;51(4):1420-9.
2. Clinical Medicine (Medicina clinica) 2005 Mar 19;124(10): 388-95.
3. Obesity Research 13:662-669 (2005).
4. Diabetes 55:924-928, 2006.
5. Journal of Nutritional Science & Vitaminology. 1999 Oct; 45(5):655-65.


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H.R. Zadeh
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