A Newly Published Study Associates Alcoholic-Induced Liver Damage to The Abnormal Metabolism of an Essential Nutrient

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A newly published study on Alcoholic Liver Disease (Steatohepatitis) suggests that alteration in the metabolism of an essential nutrient (methionine) leads to the reduced levels of molecules (glutathione) needed to counter alcohol-induced liver injury and reviews the dietary supplementation of methionine, as a treatment. Nutri-Med Logic Corp agrees that consumption of alcohol causes such alteration but states that another culprit in alcohol-induced liver injury is the hyperactivity of a gene, which could be moderated through supplementation of another nutrient: Poly-Enyl-Phosphatidyl-Choline.

A newly published study investigates the dietary supplementation of an essential nutrient (methionine) as a potential treatment for the alcohol-induced liver damage. Concurring, in most part, with the investigation of this study, Nutri-Med Logic Corp states that countering alcohol-induced liver injury depends on the proper activities of a pro-oxidant gene (CYP2E1), as well as the availability of nutrients such folate and choline (methyl group), which increase the levels of methionine and ultimately the production of a potent anti-oxidant (glutathione). However, Nutri-Med Logic Corp adds that any nutrient capable of contemporaneously providing the methyl group as well as directly moderating the activities of the pro-oxidant gene takes precedence.

One such important nutrient is Poly-Enyl-Phosphatidyl-Choline, an extract of soy that has been the target of studies for more than two decades, for its therapeutic potentials in Alcohol-induced Fatty Liver, Hepatitis, Fibrosis and Cirrhosis.

Elimination of alcohol takes place in two parts: converting alcohol to acetaldehydes and then to acetate. While acetate is harmless, known and used by the body, but acetaldehydes are one of the most damaging molecules implicated in pathology of alcohol-induced liver diseases, vitamin inactivation, hangover and even suggested to alter neurotransmitter, thus causing addiction.

The xenobiotics, elimination of foreign substances such as alcohol, is mainly done through a process called phase II enzymes. Glutathione, an endogenous anti-oxidant, represents the most powerful component of the phase II enzymes.

According to this published study, alcohol alteration of methionine reduces the availability of glutathione, which together with the hyperactivity of the pro-oxidant gene CYP4502E1 exert injuries to the liver.

Production of glutathione through methionine is dependent on the methyl group of folate or choline; the difference being that folate contains one methyl group but choline (betaine) contains three methyl groups. Studies going back to 1954 have established that alcohol consumption increases the requirement of choline intake. J Exp Med. 1954 Dec 1;100(6):615-27In conclusion.

Availability of methyl, through choline, increases the production of glutathione, needed to counter acetaldehydes. Poly-Enyl-Phosphatidyl-Choline is a pure and potent dietary source of choline.

On the other hand, alcohol-induced hyperactivity of the gene CYP2E1 not only results in accumulation of fat in the liver, producing alcoholic fatty liver, alcoholic hepatitis but also results in conversion of liver’s stellate cells to myofibroblasts and the subsequent production of collagens, which ultimately results in fibrosis and cirrhosis.

Poly-Enyl-Phosphatidyl-Choline, contains a component called DLPC (dilinoleoy-Phosphatidylcholine), which a plethora of studies have conclusively demonstrated its ability to moderate the alcohol-induced hyperactivities of the pro-oxidant gene CPY2E1.

In conclusion, Nutri-Med logic Corp agrees with this recently published study and the role of methionine in Steatohepatitis as well as the inconclusive results from supplementation of methionine but adds that more than two decade of studies have produced credible and favorable results from supplementation of another nutrient: Poly-Enyl-Phoshaptidyl-Choline.

Nutri-Med Logic Corp is the producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

Nutri-Med Logic Corp is also the producer of the Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;
Producer of a Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years;

Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on the potential benefits of PolyEnylPhosphatidylcholine, Omega-3 and R-Alpha Lipoic Acid.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

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H.R. Zadeh
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