New Study on Oxidative Stress Provides Insights to Premature Aging, Diabetes, Atherosclerosis, Hypertension and Neurodegenerative Diseases

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A newly published study by National Institutes of Health on oxidative stress, more specifically in the role of Reactive Oxygen Species (ROS) on aging and a range of human diseases including diabetes, atherosclerosis, hypertension, cancer, cardiovascular and neurodegenerative diseases implicates a compromised redox homeostatic pathways. Nutri-Med Logic Corp, agreeing with this study, states that while homeostasis of redox pathways do play a fundamental role in opposing premature cellular aging and age-related diseases but homeostasis of the immune system (inflammation) is equally as important, if not more.

A newly published study, adopting the thinning of skin layers as a measure of normal or premature aging and the development of degenerative disease, states that in animal models proper anti-oxidant defense lead to normal skin aging, whereas deficiency in the anti-oxidant defense resulted in premature aging. Nutri-Med Logic Corp adds that an imbalance in the anti-oxidant defense inevitably involves the immune system and, thus, shifting its homeostasis. Accordingly, any therapeutic intervention needs to incorporate anti-inflammatory nutrients, as well.

According the study, at ideal levels, ROS play essential roles as regulatory mediators in signaling or defense processes, including the promotion of angiogenesis (blood vessel formation), erythropoietin (red blood cell) production and the destruction of bacteria and other foreign substances by immune system.

ROS is regulated by cellular anti-oxidant defense system, one of which is Superoxide Dismutase (SOD). Lower cellular levels of SOD gives rise to excessive Reactive Oxygen Species concentration. In another word, development of oxidative stress and according to this study, a growing body of evidence suggests its definitive role in premature aging and a host of human diseases ranging from diabetes, atherosclerosis, hypertension, cardiovascular diseases, neurodegenerative diseases up to cancer (DNA damage).

Nutri-Med Logic Corp states that while increasing SOD might not be effectively attainable through diet, but the concentration of an equally important internal anti-oxidant, R-Alpha Lipoic, could very well be attained through its dietary supplementation.

Both R-Alpha Lipoic and SOD are found in the mitochondria, where metabolism of glucose gives rise to the production of Reactive Oxygen Species.

Application of R-Alpha Lipoic has conclusively shown that in presence of R-Alpha Lipoic, there is reduced requirement for SOD, by the human body, indicating the importance of R-Alpha Lipoic as a key anti-oxidant nutrient. (1)

Other studies have shown that SOD presents anti-inflammatory properties, more specifically in studies relating to inflammatory Bowel Disease. (2)

Inflammation is an immune mechanism and its dysregulation is not limited to Inflammatory Bowel Disease, rather it is implicated in the same spectrum of diseases as the oxidative stress, including but limited to per-mature cellular aging, diabetes, atherosclerosis, hypertension, cardiovascular diseases, neurodegenerative diseases up to cancer.

While SOD has anti-inflammatory properties but it is not the mechanism, by which the human body resolves the inflammation. The human body resolves inflammation in two principal manners, one of which is through derivatives of Omega-3 fatty acids. The human body is incapable of producing Omega-3, thus it must be supplied through diet.

While addition of R-Alpha Lipoic is a valuable nutritional support in improving the anti-oxidant defense (redox homeostasis), contemporaneous incorporation of the most powerful anti-inflammatory nutrient (Omega-3) would improve the homeostasis of the immune system (inflammation).

In conclusion, Nutri-Med Logic Corp agrees with this important new study but adds that regulation of inflammation is equally as important, in opposing the development of age-related disease and cellular premature aging, as the regulated anti-oxidant defense.

Nutri-Med Logic Corp. is a producer dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years;

Nutri-Med Logic Corp is also the producer of the Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3.

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on the potential benefits of R-Alpha Lipoic and benefits of Omega-3 anti-inflammatory nutrient and What Is Omega-3 Good For.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to treatment or cure.

(1) J Brachial Plex Peripher Nerve Inj. 2010; 5: 15
(2) J Leukoc Biol. 2004 Sep;76(3):537-44


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H.R. Zadeh
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