A Cross-Sectional Analysis on Deficiency of Choline, a Nutrient, Results in an Important Finding for Postmenopausal Women

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A newly published study by Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, encompassing large cohort of patients with nonalcoholic fatty liver, suggests that decreased intake of choline, a nutrient, was significantly associated with increased fibrosis in postmenopausal women. Nutri-Med Logic Corp, agreeing with study, adds that this important finding opens the discussions on the adequate choline intake, previously set by the US Institute of Medicine to be the same for pre or postmenopausal women.

The result of a newly published study suggests that postmenopausal women, with an inadequate choline diet, are at higher risk of fibrosis. Nutri-Med Logic Corp adds that in 1998, the Food and Nutrition Board of the Institute of Medicine established a dietary reference intake (DRI) of choline for females based on age, but only from 0 month up to adulthood. The only other distinction, in adult females, was for pregnant or lactating mothers. The US Institute of Medicine did not consider pre or postmenopausal age as criteria for setting a corresponding choline intake.

The John Hopkins’ study encompassed 644 subject, which were grouped into children of 9-13 years old, males more than 13 years old, premenopausal women more than 18 years of age and postmenopausal women, taking into account the adequate choline intake as set by US institute of Medicine; Choline deficiency was defined to be at less than 50% of the adequate intake.

The result of the analysis suggests that postmenopausal women, with fatty liver, having a choline deficient diet had worse fibrosis.

Nutri-Med Logic Corp adds that this new study correctly opens the discussion, as to whether the Choline adequate intake for females needs to be further examined and additional classification would be appropriate for adult females, to-wit, considering the menopausal stage as a new category and same to be irrespective of the liver health of pre or postmenopausal women.

It is well established that premenopausal women might be resistant to choline deficiency due to their production of estrogen, which induces synthesis of choline via the PEMT enzyme (FASEB J. 2007 Aug;21(10):2622-32).

However, given the fact that estrogen levels begin to drop right before, during and after the menopause, further studies might be needed for the adequate choline intake in this category of adult females.

While this study took into account the fatty liver (non-alcoholic) as a factor in the severity of fibrosis but it is with a doubt that deficiency of choline, by itself, might be a cause of non-alcoholic fatty liver, in the first place.

Obviously, non-alcoholic fatty liver is associated to variety of factors, but choline deficiency remains as one of the front-runners. A search of PubMed database on choline deficient diet and studies on choline and fatty liver dates back to 1934.

Furthermore, due to estrogen, physiologically premenopausal women would have a lower choline requirement than men, but with a loss of estrogen at menopausal stage, when taking into account the result of this study, the adequate choline intake for postmenopausal women deserves a new review.

In conclusion, Nutri-Med Logic Corp agrees with this important study and adds that it might be appropriate to revisit the choline requirement for adult females and re-determine if pre or postmenopausal women would require a separate adequate intake classification.

Nutri-Med Logic Corp is the producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy, a pure and effective dietary source of choline and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

Nutri-Med Logic Corp is also the producer of the Natural, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

Producer of dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for decades;

Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on other potential benefits Poly-Enyl-Phosphatidylcholine and anti-inflammatory nutrients such as Omega-3 and What Is Omega-3 Good For.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.


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H.R. Zadeh
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