Improving the Regulation of Energy Expenditure May Reduce the Risk of Cardiovascular Diseases and Avoid Pre-Mature Cellular Aging

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A new study, published in Human Molecular Genetics, investigating the relationship between cell’s ability to produce energy and aging points to a regulator of metabolism for improving cellular pre-mature aging. Nutri-Med Logic Corp agrees with this study and adds a competent body of evidence has suggested that the function of this regulator as well as the cellular energy homeostasis could be improved by R-Alpha Lipoic, a nutrient and a vital co-enzyme in the production of human cellular energy.

A newly published study suggests, in animal models, an increased activity (expression) of a regulator of metabolism, PGC-1 Alpha, may improve pre-mature cellular aging. Nutri-Med Logic Corp, agreeing with this notable study, adds that credible research and evidence has pointed to R-Alpha Lipoic, a nutrient and a vital co-enzyme in the production of energy, as a viable mean to improve the activities of this regulator.

According to this study, by Department of Cell Biology and Anatomy, University of Miami Miller School of Medicine, Miami, FL, aging increases our vulnerability to muscle degeneration (Sarcopenia), as well as cardiovascular diseases and that the accumulated alteration (mutation) in mitochondrial (cellular energy plant) DNA caused its dysfunction leading to potentially shorter lifespan.

According to the University of Miami study, the increased expression of PGC-1 Alpha, a regulator of metabolism, while improved the mitochondrial function but did not reverse the accumulated mutation in mitochondrial DNA, rather it caused a small increase in its mutation. Nonetheless, the increased expression of muscle PGC-1 Alpha improved some premature aging phenotypes.

Suffices to say that increasing the function or capacity of mitochondria (biogenesis) results in the production of additional reactive oxygen species (oxidative stress) and the increased oxidative stress would be a contributing factor for the added mutation, in the abundance of mitochondria, as well as the copy number and integrity of mitochondrial DNA in human cells. (1)

Amongst mitochondrial anti-oxidant molecules, mitochondrial glutathione not only acts as key anti-oxidant defense against reactive oxygen species but also acts as a detoxifying enzyme, counteracting a variety of free radicals such as hydrogen peroxide, lipid hydroperoxides and xenobiotics, as well as being a co-factor for enzymes glutathione peroxidase or glutathione-S-transferase. (2)

In addition and according to The Department of Internal Medicine of University of Miami, the cellular Reduction-Oxidation (redox) is regulated by three systems, two of which are also regulated by glutathione. (3)

Overwhelming number of institutes, including the prestigious Linus Pauling Institute, have determined that Lipoic Acid (also known as R-Alpha Lipoic Acid) increases the synthesis of glutathione in the human cells.

Moreover and according to USDA/ARS Children’s Nutrition Research Center, in aged animals, the metabolic action of R-Alpha Lipoic is mediated through activating a cellular energy sensor (AMPK) that can regulate PGC-1 Alpha, a metabolic regulator. (4)

The USDA/ARS study suggests that, in animal studies, R-Alpha Lipoic Acid improves skeletal muscle energy metabolism (PGC-1 Alpha).

In conclusion, Nutri-Med Logic Corp agrees with this study and adds that R-Alpha Lipoic Acid, a nutrient and a vital co-enzyme in the production of cellular energy, offers unique health benefits such as being a potent anti-oxidant by itself, increasing the glutathione levels and most importantly improving the energy homeostasis.

Nutri-Med Logic Corp is a producer of dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, a potent anti-oxidant and the dietary supplement of choice for the Diabetics, in Germany for decades.

Nutri-Med Logic Corp is also the producer of the Natural, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy, a pure and effective dietary source of choline and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on other potential benefits of R-Alpha Lipoic Acid and anti-inflammatory nutrients such as Omega-3 and What Is Omega-3.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

1. Int J Biochem Cell Biol. 2005 Apr;37(4):822-34.
2. Antioxidants & Redox Signaling, Volume 11, Number 11, 2009
3. Drugs. 2011 Jul 30;71(11):1385-96
4. Metabolism. 2010 July; 59(7): 967–976.


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H.R. Zadeh
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