Study on Oxidative Stress and Omega-3 Suggests That at Early Stage of Rett Syndrome, a Genetic Disorder, Omega-3 Dietary Intervention Can Lead to Partial Clinical Rescue

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A new finding by Neonatal Intensive Care Unit, University Hospital Azienda (AOUS) and Le Scotte General Hospital, Italy, suggests that Omega-3 dietary supplementation decreased the severity of the symptoms and oxidative stress markers in a genetic disease, for which no effective therapy has been available. Nutri-Med logic Corp adds, while the study states that Omega-3 reduced the markers of oxidative stress, in particular in the red blood cells, but there is a distinct difference between producing anti-oxidant effects and being an anti-oxidant. Omega-3 is not an anti-oxidant rather it is an anti-inflammatory nutrient with broad protective properties, one of which applies to the protection of red blood cells against oxidative stress.

For the first time, new findings of a remarkable study, published in the March 2012 issue of Genes and Nutrition, suggests Omega-3 dietary supplementation was an effective dietary intervention in the early stage of Rett Syndrome, a Genetic Disease, which no effective therapy was previously available. Nutri-Med logic Corp adds that while oxidative stress is the hallmark of the progression of this genetic disease, the benefits of Omega-3 in reducing such oxidative stress does not make Omega-3 an anti-oxidant nutrient; rather it confirms the protective roles of Omega-3, including but not limited to producing molecules that have anti-oxidant properties. Omega-3, inherently, is an anti-inflammatory essential nutrient.

One remarkable aspect of this study was the incorporation of anti-inflammatory nutrient to combat oxidative stress, which is a key contributing factor in the progression of this disease. Oxidative stress is mainly due to lack anti-oxidant defense, which in most part involves an internal anti-oxidant called glutathione. Lack of anti-oxidant defense gives rise to excessive free radicals that consequently damage the human cells, red blood cells included.

However, studies on Rett Syndrome had previously shown that while a redox imbalance was noted, but no significant differences were found in the red blood cell cellular anti-oxidant defense, involving glutathione elements, and their control group. Nonetheless, the blood concentration of a toxic molecule called malon-di-aldehyde, a marker of oxidative stress (lipid peroxidation), is significantly increased in Rett syndrome patients. (Brain Dev. 2001 Dec;23 Suppl 1:S236-9)

Malon-di-aldehydes are the end-product of the lipid peroxidation by metals such as iron. In red blood cells and the nerve tissue, the lipid peroxidation is generally protected by a plasmalogens, a particular type of cellular phospholipid.

The rate-limiting enzymes for the production of plasmalogen are induced by the DHA Omega-3 fatty acids. (J Mol Neurosci. 2001 Apr-Jun;16(2-3):263-72; discussion 279-84)

Accordingly, while supplementation of Omega-3 would potentially offset any decrease as the result of its deficiency, as it relates to the adequate production of plasmalogens and their subsequent protective role against lipid peroxidation, but Omega-3 is not an anti-oxidant by itself. Omega-3 is an anti-inflammatory nutrient.

In conclusion, Nutri-Med Logic Corp state while this remarkable study expands the horizon, benefits and additional protective role of Omega-3, specifically in countering lipid peroxidation and/or oxidative stress on the red blood cells, but it should be strongly noted that Omega-3 is not an anti-oxidant nutrient, rather an anti-inflammatory nutrient with many noteworthy health benefits, including but not limited to cardiovascular and nervous system.

Nutri-Med Logic Corp is the producer of the Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3.

Nutri-Med Logic Corp is also a producer of dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, a potent anti-oxidant and the dietary supplement of choice for the Diabetics, in Germany for decades;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy, a pure and effective dietary source of choline and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

Nutri-Med Logic Corp invites you to visit its News Archives and Review its News Releases on other potential benefits of Omega-3 and What is Omega-3 Good For.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

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H.R. Zadeh
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