3D Biomatrix™ Releases White Paper on 3D Cell Culture as An Early-Stage Oncology Drug Discovery Tool

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3D Biomatrix, which develops and sells tools for drug discovery research and testing that mimic the human cellular environment, has released a white paper that describes the relevance of three dimensional (3D) spheroid cultures to oncology drug discovery and the use of Perfecta3D™ Hanging Drop Plates to generate monoculture and co-culture 3D spheroids and test them against anti-cancer drugs.

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3D spheroid cultures better mimic in vivo tissues than traditional 2D cultures.

3D cell and spheroid cultures can greatly increase the relevance of in vitro drug testing data, specifically for oncology drugs.

3D Biomatrix, a life sciences company developing and marketing revolutionary solutions for three dimensional (3D) cell cultures, has released a white paper highlighting the demonstrating of 3D spheroid cultures to in vitro oncology drug testing. The paper focuses on the generation of uniform and controllable spheroids within Perfecta3D(TM) Hanging Drop Plates, the use of the plates to test oncology drugs on 3D spheroids, and on the formation of several co-culture spheroid patterns that increase the relevance of 3D spheroids to in vivo tumors.

The white paper highlights oncology drug testing data presented in the journal Analyst [1] that demonstrates that the drug toxicity profile will vary greatly depending on if drugs are tested in two-dimensional (2D) or 3D cultures. The mechanisms of the many drugs that depend on the 3D structure of human tissues (e.g., hypoxia-trigger cytotoxins) may not be represented in 2D formats. The white paper continues to describe several patterned co-cultures, originally published in the journal Biotechnology and Bioengineering [2], that by including several cell types will increase the relevance of spheroid cultures to in vivo tissues. Furthermore, these co-culture configurations can advance studies on cellular migration and metastasis, cell-cell signaling, and other cell-cell interactions.

“3D cell and spheroid cultures can greatly increase the relevance of in vitro drug testing data, specifically for oncology drugs, because they are the best human body model early in the research process,” says 3D Biomatrix CEO Laura Schrader. “The industry and patients alike can only benefit, and this white paper will convince researchers of how necessary 3D cell cultures are in oncology drug testing.”

A downloadable version of the white paper is available at the 3D Biomatrix website: http://3dbiomatrix.com/white-paper-3/

[1] Tung et al. High-throughput 3D spheroid culture and drug testing using 384 hanging drop array. Analyst, 2011, 136, 473-478.
[2] Hsiao et al. 384 Hanging Drop Arrays Give Excellent Z-factors and Allow Versatile Formation of Co-culture Spheroids. Biotechnology and Bioengineering, 2011.

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