Association Between Rheumatoid Arthritis and Systemic Bone Loss Highlights the Importance of Omega-3 Anti-Inflammatory Diet

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A newly published study, in the Rheumatology International, finds a relation between an inflammatory agent, found in Rheumatoid Arthritis patients, and early bone loss. The study suggests repressing this inflammatory agent as a remedy for treatment. Nutri-Med Logic Corp, agreeing with this study, adds that while supplementation of nutrients such as calcium and vitamin D are highly important in combating osteoporosis but this study correctly identifies an under-looked but yet an important cause of bone loss: ”Inflammation.”

A newly published study states that an inflammatory agent “IL-6” implicated in the manifestation of Rheumatoid Arthritis (RA) plays a key and fundamental role in bone loss in RA patients. Nutri-Med Logic Corp, agreeing with this study, adds that an uncontrolled inflammation not only results in bone loss in RA patients, but also remains a key cause of the osteoporosis in general population and thus more emphasis is needed for the incorporation of Omega-3 anti-inflammatory diet.

While calcium and vitamin D are taking the front stage, as the dietary intervention of choice to prevent and/or improve osteoporosis, but it is the inflammation that remains the main culprit, yet it has been the most under-looked cause of osteoporosis.

Calcium is a key component of the bone matrix. However, absorption of calcium is dependent on two key factors: Homeostasis of inflammation and availability of a group of other minerals, those being vitamin D, vitamin K, phosphate, baron, manganese and magnesium.

Even with adequate intake of calcium and its mineral group, osteoporosis is very likely if inflammation remains dysregulated.

This study correctly identifies an inflammatory agent “IL-6”, found in RA patients, and relates it to bone resorption in this group. However, excess production of IL-6 not only is the cause of bone loss in RA patients but also the key and fundamental player in the development and progression of osteoporosis.

IL-6 is an important biologic molecule that separates the work of bone-making cells and bone-removing cells. IL-6 activates the bone resident immune cells (macrophages) and converts them to osteoclasts, which are the bone-removing cells.

The genes that produce IL-6 share a binding site with another gene that produces the master switch of inflammation, that being NF-kB, whereas activation of one results in the activation of the other. (Proceeding of National Academy of Science, Vol. 90, pp. 10193- 10197, Nov. 1993.)

Moderation and/or inhibition of NF-kB is the key target of most, if not all, osteoporosis medication.

According to studies by the Department of Experimental Medicine and Oncology, University of Turin, Italy, NF-kB could also be moderated by means of a suitable dietary intake of Omega-3.

Omega-3 Adequate Intake (AI) recommendation, from the Food and Nutrition Board of The U.S. Institute of Medicine (IOM) stands at 1.1 to 1.6g/d (gram per day) for Women and Men, respectively, in order to prevent its deficiency and/or promote health. The IOM is the health arm of the National Academy of Sciences, which works outside of government to examine the US nutritional well-being, establishes the Adequate Intake (AI) of nutrients, as well as providing guidance about the application of nutrition and food sciences to improve human health.

In conclusion, Nutri-Med Logic Corp agrees with this study but adds that dysregulated inflammation is the key cause of bone loss, not only in RA patient but in the general population, as well. Nutri-Med Logic Corp adds that more emphasis is needed for the incorporation of an anti-inflammatory nutrient in daily diet.

Nutri-Med Logic Corp is the producer of the Natural, Balanced, Deodorized, Concentrated & Pharmaceutical Grade. Omega-3 is the most effective anti-inflammatory nutrient.

Nutri-Med Logic Corp is also a producer of dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid (the natural type of Lipoic Acid), a universal anti-oxidant and the dietary supplement of choice for the Diabetics, in Germany for decades;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy, a pure and effective dietary source of choline and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

Nutri-Med Logic Corp invites you to visit its News Archives and Review its News Releases on other potential benefits of Omega-3 Fatty Acids.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, statements or sources above have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

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H.R. Zadeh
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