New Study Relates Parkinsons to Inadequate, Impaired Anti-oxidant Defense and Detoxification

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A newly published study suggests that inadequate anti-oxidative defense or impaired detoxification and enhanced deposition of iron in the brain result in the demise of dopamine neurons and thus the development of Parkinson’s. The study further points to the depletion of glutathione, an internal anti-oxidant, as a cause of Parkinson’s. Agreeing with this study, Nutri-Med Logic Corp adds, glutathione is a potent biological anti-oxidant, detoxifying molecule and overwhelming number of studies have presented credible evidence that dietary intake of R-Alpha Lipoic, a nutrient, increases the glutathione levels and opposes deposition of iron.

A new study by Université Libre de Bruxelles, Bruxelles Belgium, recipient of four Nobel Prizes, states that the decrease in internal antioxidants and detoxifying molecules gives rise to higher production of free radicals, lower cellular energy production and thus contribute to neuro-degeneration of dopamine neurons and development of Parkinson’s.

Dopamine is a biological organic chemical produced by dopamine neurons and amongst its many vital applications is responsible for movement control. With pre-mature death of dopamine neurons and/or reduction in the available dopamine (more than 10 percent) involuntary movement will ensue.

The part of the brain that contains high concentration of dopamine neurons (Substantia Nigra) is also the storage area for a particular iron containing protein called ferritin, which keeps iron in a non-toxic form. Iron promotes important metabolic processes in the brain and the ferritin inside the cells is safely stored and regulated.

An imbalance between two vital co-enzymes NAD/NADH (too much of NADH), inside the cells, generates "reductive stress" leading to the release of iron from ferritin, in another word transition of non-toxic iron to toxic iron, now producing oxidative stress and contibuting to degeneration of dopamine neurons. NAD and NADH are both involved in cellular energy production.

Dr. David Sinclair, a professor of Pathology at Harvard Medical School, has proposed that mitochondria (cellular energy plant) survival would be nutrient-sensitive and nutrients that could increases the levels of the co-enzyme NAD would contribute to the survival of cells, such as dopamine neurons.

Studies have shown that under conditions of "reductive stress," Alpha Lipoic Acid has decreased high NADH levels in the cell by utilizing it as a co-factor for its own reduction process. (1)

Decreasing NADH [removing its hydrogen (H)] results in an increase in the levels of NAD. Proper NAD/NADH eliminates a key cause of "reductive stress" and, thus, opposes an important factor for the conversion of non-toxic iron, from ferritin, to a free toxic iron.

The study also reports that depletion of glutathione was observed in postmortem studies of brain tissues of Parkinson's patients and, additionally, the synthesis of dopamine by itself requires presence of other biological molecules (tetrahydrobiopterin), which also contribute to the production of free radicals and the subsequent degeneration of dopamine neurons, absent of an adequate anti-oxidants defense such as adequate glutathione.

Glutathione is one the most potent internal anti-oxidants and detoxifying molecules and in 1996, Dr. Lester Packer, professor of Molecular Biology at Berkeley discovered that Alpha Lipoic Acid, a dietary nutrient and an antioxidant itself, stimulates the production of glutathione. According to Dr. Packer, Alpha Lipoic Acid is readily absorbed, when taken orally.

In conclusion, Nutri-Med Logic Corp agrees with this study, to which inadequate anti-oxidant defense, specifically decline in glutathione, together with deposition of iron contribute to premature death of dopamine neurons and development of Parkinson’s. Nutri-Med Logic Corp adds that credible evidence suggests that dietary intake of R-Alpha Lipoic, a nutrient, opposes both oxidative stress and reductive stress, through increasing glutathione levels and improving the homeostasis of NAD/NADH.

Nutri-Med Logic Corp is the producer of the Natural, Balanced, Deodorized, Concentrated and Pharmaceutical Grade Omega-3. Omega-3 is the most effective anti-inflammatory nutrient.

Nutri-Med Logic Corp is also a producer of dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid (the natural type of Lipoic Acid), a universal anti-oxidant and the dietary supplement of choice for the Diabetics, in Germany for decades;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy, a pure and effective dietary source of choline and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

Nutri-Med Logic Corp invites you to visit its News Archives and Review its News Releases on other potential benefits of Omega-3 Fatty Acids.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, statements or sources above and below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

1. Biochemical pharmacology. 1997, vol. 53, no3, pp. 393-399 (34 ref.)

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H.R. Zadeh
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