Although conducted in experimental mice, the results of the study indicate that sodium phenylbutyrate may also help in the suppression of inflammation of the brain, as well as decrease the production of fat deposits in the brain.
Past News ReleasesRSS
Toronto, ON (PRWEB) July 07, 2012
Bel Marra Health, well known for offering high-quality, specially formulated vitamins and nutritional supplements, supports a recent study that shows there could be promise in the treatment of Parkinson’s disease.
It a recent medical report published in the June issue of the journal PLoS One, the treatment of experimental mice with symptoms similar to Parkinson’s disease using sodium phenylbutyrate resulted in an improvement in brain motor function and normalized the activities of brain cells, possibly resulting in a decreased risk of cognition and forgetfulness. Sodium phenylbutyrate was initially considered as a treatment for disorders involving the urea cycle, which is a biochemical reaction that helps in the excretion of wastes such as urea and ammonia through the kidneys and liver. Individuals suffering from a disorder involving the urea cycle are unable to move these toxic wastes, thus requiring immediate treatment.
According to the PLoS report, treatment of experimental mice with sodium phenylbutyrate resulted in a decrease in the production of inflammatory molecules that were signs of brain degeneration. The amount of cholesterol was also lower after treatment with the drug, decreasing the chances of fat deposition between nerves in the brain, which may result in symptoms of Parkinson’s disease, including forgetfulness and unstable behavior.
Spokesperson for Bel Marra Health Dr. Victor Marchione commented on the findings saying, “Interestingly, the treatment of these mouse models of Parkinson’s disease simply involved oral administration of the drug. The mice also did not show any signs of toxicity, although the dose used in the treatment was lower than that employed in urea cycle disorders. In another experiment using the mice, the treatment of sodium phenylbutyrate resulted in the improvement in motor functions, including an increase in the speed and distance that they have traveled in a defined laboratory setup.” Dissection of the brain of each mouse showed that the expected amount of free radicals present in the tissues were significantly decreased, suggesting that the risk of forgetfulness and other mental activities improved after treatment with sodium phenylbutyrate.
Other molecules that represented inflammation of the cells of the brain also decreased, suggesting that the treatment with the drug may serve as a potential cure for Parkinson’s disease. Measurement of dopamine production in the animal models also showed normalized levels, thus suggesting that the drug might possess a capacity in preventing further deterioration of Parkinson’s disease. Dopamine production has earlier been strongly linked with the degree of forgetfulness or memory loss in various mental health disorders.
CEO of Bel Marra Health Jim Chiang says, “This recent report appears to be a promising approach in the treatment of Parkinson’s disease. Although conducted in experimental mice, the results of the study indicate that sodium phenylbutyrate may also help in the suppression of inflammation of the brain, as well as decrease the production of fat deposits in the brain, which are the major causes of forgetfulness in Parkinson’s disease.”
(SOURCE: “PLoS One” Sodium Phenylbutyrate Controls Neuroinflammatory and Antioxidant Activities and Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease, June 18, 2012)
Bel Marra Health, as the distributor of Smart Pill, offers high-quality vitamins and nutritional supplements in formulations designed to address specific health concerns. All ingredients are backed with scientific evidence. Every product is tested for safety, quality, and purity at every stage of the manufacturing process. Furthermore, Bel Marra Health products are produced only in Health Canada approved facilities, going that extra mile to ensure our health conscious customers are getting top quality products. For more information on Bel Marra Nutritionals visit http://www.belmarrahealth.com or call 1-866-531-0466.
Bel Marra Nutritionals, Inc.
100-7000 Pine Valley
Woodbridge, ON L4L 4Y8