The rapid excretion of the synthetic protein also suggests that this pain relief format may not be optimal in treating migraines because it is not retained in the body for at least 24 hours in order for the pain symptoms to fully dissipate.
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Toronto, ON (PRWEB) July 13, 2012
Bel Marra Health, well known for offering high-quality, specially formulated vitamins and nutritional supplements, supports recent research that shows promise in the reduction of migraine occurrences.
In a recent study published in the medical journal Translational Neuroscience, the administration of a modified protein drug to mice has resulted in the reduction in the occurrence of migraines. The principle behind this pain relief study was based on the direct targeting of the nerves that were responsible in developing migraines.
Previous studies have shown that migraines are due to the continuous sensitivity and responsiveness of protein channels on the membranes of nerve cells. The hypersensitivity of protein channels generally triggers a battery of cellular reactions that ultimately result in severe headaches. Biomedical researchers have thus embarked on various research studies that focus on identifying an effective pain relief format that can prevent the hypersensitivity of these nerve protein channels. In the current study, researchers synthesized a protein called CBD3, which prevents the protein channels from binding with other proteins that result in the pain that is characteristic of migraines.
The binding mechanism behind the pain relief using the CBD3 protein drug mainly involves the decrease in the sensitivity of the protein channel to other proteins. It has been theorized that when other proteins bind to the protein channels of the nerve cells of the brain, a cascade of reactions occur, which ultimately result in pain and headache. The introduction of the synthetic CBD3 protein thus results in its occupancy within the protein channels, inhibiting its further interaction with other proteins, thus facilitating pain relief.
The synthetic CBD3 protein drug was also introduced into experimental mice with migraine headaches to monitor its effects on pain. The mice, which received the synthetic protein through injection into their abdomen, showed the absence of pain for approximately four hours. In addition, the synthetic CBD3 protein was excreted in the urine soon after the experiment, suggesting that this pain relief formulation is easily removed from the body and thus may not pose any threat to the general health of the experimental animals.
However, Spokesperson for Bel Marra Health Dr. Victor Marchione says, “the rapid excretion of the synthetic protein also suggests that this pain relief format may not be optimal in treating migraines because it is not retained in the body for at least 24 hours in order for the pain symptoms to fully dissipate.”
Another synthetic pain relief formulation, G14F, was also tested for its effects on pain related to migraines. Using experimental mouse models of migraine headaches, the administration of G14F showed extended pain relief, much longer than the CBD3 protein drug
The results of the study showed that the administration of synthetic proteins as drugs against headache pain might be more effective than current pain relief formulations. The synthetic protein drugs tested in the research study directly targeted the protein channels present at the terminal ends of nerves, preventing them from reacting to external stimuli that eventually generate pain. CEO of Bel Marra Health Jim Chiang, “The pain relief that resulted from the introduction of the synthetic protein drugs suggests that these new therapeutic options may be used for recurrent headaches, to improve the symptoms that generally characterize this chronic disorder.”
(SOURCE: “National Institutes of Health”, A PEPTIDE UNCOUPLING CRMP-2 FROM THE PRESYNAPTIC Ca2+ CHANNEL COMPLEX DEMONSTRATES EFFICACY IN ANIMAL MODELS OF MIGRAINE AND AIDS THERAPY-INDUCED NEUROPATHY, March 2012)
Bel Marra Health, the maker of Joint Rescue, offers high-quality vitamins and nutritional supplements in formulations designed to address specific health concerns. All ingredients are backed with scientific evidence. Every product is tested for safety, quality, and purity at every stage of the manufacturing process. Furthermore, Bel Marra Health products are produced only in Health Canada approved facilities, going that extra mile to ensure our health conscious customers are getting top quality products. For more information on Bel Marra Nutritionals visit http://www.belmarrahealth.com or call 1-866-531-0466.
Bel Marra Nutritionals, Inc.
100-7000 Pine Valley
Woodbridge, ON L4L 4Y8