SwitchGear Genomics Expands LightSwitch Luciferase Assay System™ by Adding Custom Cloning Services

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SwitchGear Genomics has launched a new service group to offer custom cloning and mutagenesis in the LightSwitch Vector system to complement SwitchGear’s genome-wide collection of human promoter and 3’UTR reporters

Researchers can save months of time by using SwitchGear’s cloning expertise to deliver all of the validated reporter vectors needed for their projects.

SwitchGear Genomics Inc., a leading provider of products for studying the regulatory elements in the human genome, today announced the launch of a new service group for custom cloning and mutagenesis. These services will provide customers new ways to access the LightSwitch Luciferase Assay System™, a comprehensive reporter assay platform for studying transcriptional and post-transcriptional gene regulation. The unique system includes a genome-wide collection of assay-ready GoClone™ promoter and 3’UTR luciferase reporters paired with optimized LightSwitch Luciferase Assay Reagents. The GoClone reporter vectors utilize a novel luciferase gene and a unique luciferase reagent specifically developed by SwitchGear to provide industry-leading brightness and sensitivity.

“In addition to the 18,000 human promoter reporters and 12,000 human 3’UTR reporters already cloned into the LightSwitch System, we now offer services to clone any fragment from the human, mouse, or rat genome into any LightSwitch luciferase reporter vector,” said Nathan Trinklein, Ph.D., co-founder and CEO of SwitchGear Genomics. “Researchers can save months of time by using SwitchGear’s cloning expertise to deliver all of the validated reporter vectors needed for their projects.”

SwitchGear Genomics has also announced a new comprehensive site-directed mutagenesis service to create any sequence variant within any of the company’s pre-cloned or custom built LightSwitch vectors. Site-directed mutagenesis allows researchers to map the functional sequences in a regulatory element down to a single base pair of DNA.

Shelley Force Aldred, Ph.D., co-founder and President of SwitchGear Genomics added, "By providing a fully optimized luciferase system with pre-built constructs and custom services, SwitchGear has created a one-stop reporter assay solution that enables researchers to rapidly measure regulatory element activity for any gene from the human or mouse genomes.”

About SwitchGear Genomics, Inc.:
SwitchGear Genomics Inc. is a leading provider of innovative products for studying gene regulation in the human genome. The company has developed a comprehensive approach to generate new insights into gene regulatory networks, allowing researchers to efficiently screen entire pathways in living cells. SwitchGear was founded in March 2005 by Dr. Richard Myers, Dr. Nathan Trinklein and Dr. Shelley Force Aldred from Stanford University. For more information about SwitchGear, please visit the company’s website at http://www.switchgeargenomics.com

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Nathan Trinklein, Ph.D.
SwitchGear Genomics
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