Omega XL Reports New Independent Study: Omega-3s Protect The Heart Against Adverse Effects Associated With Air Pollution

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The findings of a recent epidemiological study suggested that omega-3 fatty acids, such as found in Omega XL®, blunted cardiac responses to air pollution exposure.

The results of this study provide stronger evidence of the role omega-3 fatty acids play in alleviating cardiovascular effects of pollution

It is well documented that exposure to particulate matter in the air can increase cardiovascular disease and related deaths. Just in California, fine particulate air pollution is estimated to cause 9,000 premature deaths per year. In the first study of its kind, omega-3 fatty acids, such as found in Omega XL®, reduced lipid changes in the blood brought on by breathing particulate matter. More indirectly, the study demonstrated that omega-3 fatty acids might relax blood vessels, lowering blood pressure and affecting nervous system signals that control heart rhythm.

To date, no controlled studies have examined the association between air pollution and Heart Rate Variability. Defined as the variation in the time intervals between heartbeats, Heart Rate Variability is a measure of cardiovascular health. Low variability indicates the heart is poorly controlled by the autonomic nervous system – a part of the nervous system that regulates key involuntary functions of the body – and thus the risk of heart disease is increased.

In the study, conducted at the National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, and published in the journal of Environmental Health Perspectives, 29 healthy middle-aged participants were supplemented in a randomized, double-blind protocol with either an omega-3 supplement or olive oil (placebo) for 4 weeks before sequential chamber exposure to either filtered air or ultra fine particulate matter for two hours.

The researchers found that after exposure to the high levels of particulate air pollution, heart rate variability decreased significantly in the placebo group. In contrast, the subjects taking omega-3s showed little change. Researchers also found that the placebo group showed an immediate increase in two types of lipid levels in the blood -very low-density lipoprotein and triglycerides - after exposure to particulate matter compared to the omega-3 group.

These data identified two ways in which omega-3 fatty acids offered protection against particulate exposure. First, heart rate variability measures differed between the omega-3 and placebo groups. Omega-3s protected against changes to the involuntary nerve controls that regulate the electrical signals guiding how often the heart beats (rhythmia) and how quickly it can recover. Low heart rate variability is associated with death and arrhythmia.
Second, exposure to the air pollution changed blood lipid levels in the placebo group. After pollution exposure, an upsurge in the types of lipids linked to heart disease and atherosclerosis were measured in those taking a placebo but not in those taking omega-3 supplements.

Many people in the world are exposed to particulate air pollution that may be contributing to ill health. The results of this study provide stronger evidence of the role omega-3 fatty acids play in alleviating cardiovascular effects of pollution than other human studies done to date.

Omega XL is one of only two Omega-3 supplements sold in the world that contains the patented stabilized marine lipid extract PCSO-524™ derived only from the New Zealand green-lipped mussel, with 30 healthy fatty acids including DHA and EPA. Sold in other parts of the world under its sister brand name Lyprinol, Omega XL is manufactured exclusively by Great HealthWorks Inc., and is the most widely available omega-3 fish oil supplement containing the potent PCSO-524™ marine lipid extract. To find more information about Omega XL and PCSO-524™ visit

Source: Journal of Environmental Health Perspectives
Omega-3 Fatty Acid Supplementation Appears to Attenuate Particulate Air Pollution–Induced Cardiac Effects and Lipid Changes in Healthy Middle-Aged Adults
Environ Health Perspect 120(7) July 2012: doi:10.1289/ehp.1104472

About Great HealthWorks, Inc.
Great HealthWorks, founded in 2003, is a global manufacturer and distributor of one-of-a-kind, natural products. Great HealthWorks, the makers of Omega XL®, an all-natural, highly purified marine lipid extract from the green-lipped mussel (Perna Canaliculus) known as PCSO-524™. This patented marine lipid complex comes exclusively from the pristine waters of the Marlborough Sounds in New Zealand, and contains 30 healthy fatty acids. Great HealthWorks corporate headquarters and distribution center are in Hollywood, Florida. To find out more about Great HealthWorks, visit And for more information about the benefits of Omega XL, visit Join the conversation:

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Miles Dupree
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