Study Reveals that Active Ingredient in Depakote Does Not Disrupt Dormant Reservoirs of HIV, the Consumer Justice Foundation Reports

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The Consumer Justice Foundation, a for-profit corporation whose team of professional consumer advocates provides free online informational resources regarding the potential dangers associated with the use of certain prescription medications, has a Web site URL that can be found at http://www.depakotebirthinjury.com. The CJF hereby alerts the public to the results of a study that concluded that the use of valproic acid, the active ingredient in Depakote, does not disrupt the dormant reservoirs of HIV in people who suffer from this disease.

The Consumer Justice Foundation, a for-profit corporation whose team of consumer advocates provides free online information regarding the potential risks associated with the use of certain prescription medications, hereby alerts the public of the conclusions drawn in a study that looked at different drug therapies for people suffering from HIV. The study concluded that the use of valproic acid, the active ingredient in Depakote, does not disrupt the dormant reservoirs of the HIV virus that exists inside the bodies of patients.

The study, which was published in the July issue of Nature magazine, was conducted by researchers at the University of North Carolina at Chapel Hill. The research was led by David Margolis and the study hypothesized that vorinostat could reduce latent HIV infection in vivo. Vorinostat is a substance that some believe can help treat HIV patients.

The study concluded that “the quiescence of latent, integrated HIV provirus within resting CD4+ T cells, a significant barrier to the eradication of HIV infection, can be disrupted by an achievable and tolerable exposure to an HDAC inhibitor.” The researchers further concluded that additional research regarding this protocol should be done.

In terms of the role of valproic acid within this study, it was given to a group of HIV patients as well, and over the course of the research it did not show a tendency to disrupt the cells of dormant HIV that tend to exist within the bodies of patients even after active HIV cells have been successfully treated by other forms of medication.

Valproic acid is the active ingredient in Depakote, and Depakote has traditionally been used as an anticonvulsant medication that is prescribed to treat such conditions as migraine headaches, epilepsy and the manic episodes associated with bipolar disorder. It was included in this study because it has shown a tendency to provide other potential benefits to those who use it.

About the Consumer Justice Foundation

The Consumer Justice Foundation, whose Web site is located at http://www.consumerjusticefoundation.com, is a public resource that's been built and maintained by a group of concerned professionals who want to provide general information for consumers regarding the potential dangers involved with the use of Depakote while pregnant. This resource is not to be considered as medical or legal advice, which should only be dispensed by a licensed medical doctor or a Depakote lawyer.

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Faith Anderson
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