Toronto, Canada (PRWEB) September 10, 2012
PD-1 is a key immunological checkpoint expressed by activated T cells. PD-1 mediates immunosuppression by modulating the TCR signaling machinery, thus preventing uncontrolled inflammation and autoimmunity. In chronic inflammatory conditions, sustained PD-1 expression on responsive effector lymphocytes drives T cells to a state of impairment known as functional exhaustion. Functionally impaired CD4 and CD8 T cells have been described in varied conditions, including cancer and chronic viral infections such as SIV, HIV and Hepatitis C. A common immunological factor to these different pathologies is the co-expression of immune inhibitory markers such as PD-1, CD160 and TIM-3.
In the context of drug discovery and clinical monitoring efforts, the ability to characterize the immune inhibitory profile of responding lymphocytes, and to discriminate between functionally activated cells versus exhausted cells, is of fundamental importance. Multiparametric flow cytometry has become the platform of choice for characterization of lymphocyte populations, enabling phenotypic and functional analysis of mixed cell populations such as in peripheral blood.
In this webinar, case studies will be presented to demonstrate how advanced immune monitoring tools have been used to gain insight on the proportion of major lymphocyte subsets, their response to various stimuli and their activation versus exhaustion status. Participants will learn how immune monitoring is being deployed to assess immune system status and to advance drug development and clinical monitoring efforts.
For more information or to register go to http://xtks.in/xto-512.
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