La Peer Physicians Comment on New Research Linking Biological Markers of Obesity with Cancer Risk in Barrett’s Esophagus Patients

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Directors of La Peer Health Systems’ Barrett’s Esophagus Center of Excellence in Los Angeles are intrigued by new research revealing biomarkers may be used to assess cancer risk in Barrett’s esophagus patients.

Peyton Berookim MD
This research provides valuable insight into esophageal cancer predispositions, which in turn could lead to preventative treatment options. Prevention is the number one way to treat cancer.

A recent article showed that insulin and leptin, biological markers of obesity, may correlate with cancer risk in Barrett’s esophagus patients. Doctors at the Barrett’s Esophagus Center of Excellence are intrigued by the findings that can influence the way they treat and prevent Barrett’s esophagus from progressing to cancer.

According to Dr. Peyton Berookim, one of the medical directors at the Barrett’s Center, “This research provides valuable insight into esophageal cancer predispositions, which in turn could lead to preventative treatment options. Prevention is the number one way to treat cancer.”

Barrett’s esophagus patients are more likely to develop esophageal cancer, and a greater understanding of how the disease develops could potentially save lives. Biological markers associated with obesity include leptin, a regulator of hunger, and insulin, a regulator of blood sugar levels. In this study, sensitivity to both leptin and insulin was analyzed in Barrett’s esophagus patients to determine a link with the development of esophageal adenocarcinoma (cancer of the esophagus). Medical researchers found that increased levels of leptin and insulin resistance correlate with a higher risk of developing esophageal cancer.

“We know obesity is linked to the development of Barrett’s esophagus and its progression to cancer. Now we can link cancer even more closely to biological markers, which will give us a more advanced knowledge of the course of progression,” explained Mark Davidson, MD, another director at the Barrett’s Esophagus Center of Excellence.

Esophageal cancer can be harder to detect in its earlier stages, because of its asymptomatic presentation. Doctors at the Barrett’s Esophagus Center of Excellence are experts in esophageal cancer treatment and prevention. Preventative treatment procedures include radiofrequency ablation therapy to remove cancerous tissue. Using the state-of-the-art HALO System, doctors are able to remove precancerous cells from the lining of the esophagus to reduce a patient’s risk of developing cancer in the future.

La Peer Health Systems is an outpatient surgery center in Beverly Hills, founded by doctors and focused on providing excellent patient care alongside the most cutting-edge medical treatments available. With 40 world-renowned physicians in 13 specialties, we offer comprehensive medical treatment that takes patients from consultation to diagnosis, treatment, surgery, and ultimately aftercare. Our 13 medical departments include orthopedics & sports medicine, gastroenterology, head & neck surgery, colorectal & general surgery, podiatry, ophthalmology, pain management, plastics & reconstructive surgery, gynecology, spine surgery, interventional cardiology, bariatric surgery, and anesthesiology. Unlike large hospitals, La Peer's unique structure offers extremely personal care in a safe and controlled environment.

To learn more about the Barrett’s Esophagus Center of Excellence visit http://www.barrettsMD.com.

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Risa Luksa

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