DSTL's Approaches to Generic Sample Preparation for the Detection of Biological Agents to be Presented at Knowledge Foundation’s Sample Prep 2013 Conference

Share Article

Sample Prep 2013 - May 9-10, 2013 - San Diego, CA

Sample Prep 2013

Industry leaders from around the world will convene in San Diego, CA for the Knowledge Foundation’s 7th Sample Prep 2013 conference which will take place at the San Diego Hilton & Resort on May 9 – 10. One of the many anticipated presentations will include Martin McDonnell, PhD, of the Defense Science and Technology Laboratory (DSTL) as he present “Approaches to Generic Sample Preparation for the Detection of Biological Agents in the Environment”

Presentation Abstract:

“Approaches to Generic Sample Preparation for the Detection of Biological Agents in the Environment”
Martin McDonnell, PhD, Defense Science and Technology Laboratory (DSTL)

High confidence detection of potentially hazardous pathogenic micro-organisms and protein toxins in the environment requires effective and rapid sample prep. As the consequences of a positive alert in either military or civilian settings could be severe, it is desirable that monitoring is performed using at least two very different detection technologies, including, for example immunoassay, nucleic acid or mass spectrometry-based methods. To meet this requirement, the sample prep should ideally be generic, with an output sample suitable for a broad range of sensor types. When added to the high variability of environmental backgrounds, including both biological and non-biological materials, and the need to deal with multiple sample inputs including, for example aerosols, soils, vegetation, or waste water, the development of such a system represents a significant technical challenge. In order to perform its required role, the sample prep system may perform sample maceration and agent extraction, selective background and interferent removal, agent clean-up, concentration and lysis for antigen and nucleic acid release. This requires the use of a range of processing technologies which must be capable of integration into a fully automated system capable of being used in the field by non-expert users. This presentation will describe progress in the development of such a generic integrated sample prep system in a project involving DSTL, academia and industry.

Sample Prep 2013 Program topics will include:

  • Robust methodologies for sample collection, (pre-)concentration, lysis, and target extraction
  • Critical role of sample prep in early diagnostics
  • Rapid sample-to-sequence techniques
  • Point-of-care sampling, detection and analysis
  • Sample preparation with micro- and nano fluidics
  • Robust sampling methodologies (automation, high-throughput, combinatorial approach in sample prep)
  • Alternative amplification techniques for sensitive sample prep
  • End-user prospective for biodetection and sampling technologies and devices
  • Alternative and disruptive approaches to sample preparation and applications
  • Field-ready devices: compatibility/reliability/scalability
  • Target enrichment and background depletion techniques
  • Isolation of dilute objects on cell and molecular levels
  • Immiscible phase purification
  • Novel methods of extraction from tough (non-filterable) matrices
  • Nucleic acid and protein based sample prep for next generation sequencing
  • Nanotechnology and miniaturization challenges for sample preparation
  • Standardization and regulatory issues in sample preparation across different applications

Distinguished Speaker Faculty:
-Charles Young, PhD, The Johns Hopkins University
-Richard Allen, PhD, Luminex Corporation
-John C. Carrano, PhD, Paratus Diagnostics, LLC
-Forest L. Rohwer, PhD, San Diego State University
-Sarah Fakih, PhD, QIAGEN GmbH, Germany
-Season Wong, PhD, AI Biosciences, Inc.
-Michael J. Heller, PhD, University of California San Diego
-Martin McDonnell, PhD, Defense Science and Technology Laboratory - DSTL Porton Down, United Kingdom
-Alexis Sauer-Budge, PhD, Fraunhofer USA
-Gregory Auner, PhD, Wayne State University
-Hafsa Korri-Youssoufi, PhD, University Paris-Sud, France
-Shan Gao, PhD, Wave 80 Biosciences, Inc.
-David Wright, Wi Medical Device Development, Inc.
-Mark W. Eshoo. PhD, Ibis Biosciences Inc., an Abbott Company
-Mark Tondra, PhD, Diagnostic Biosensors
-Patrick Broyer, PhD, bioMérieux SA, France
-Andy Page, InnovaPrep LLC
-Numrin Thaitrong, PhD, National Center for Genetic Engineering and Biotechnology / Sandia National Labs
-Marek Smieja, MD, PhD, McMaster University, Canada
-Rolf O. Ehrhardt, MD, PhD, BioCision, LLC
-Vasco Liberal, PhD, Biomatrica, Inc.

About The Knowledge Foundation
The Knowledge Foundation integrates scientific ingenuity and real-world applications by fostering collaborative research at the rapidly changing intersection of science and business. Known for providing members of its Technology Commercialization Alliance with direct and unbiased state-of-the-art scientific information, the Knowledge Foundation is uniquely qualified to provide wider exposure for important developments in the emerging fields of alternative energy, nanotechnology, and chemical & biological detection technologies.

The Knowledge Foundation
2193 Commonwealth Ave, Suite 398
Boston, MA 02135-3853
Phone: (617) 232-7400
Fax: (617) 232-9171
Email: custserv(at)knowledgefoundation(dot)com
Website: http://www.knowledgefoundation.com

Media Contact:
Matt DiCecca
Conference Marketer
(617) 232-7400 ext. 203
Email: mdicecca(at)knowledgefoundation(dot)com

Share article on social media or email:

View article via:

Pdf Print

Contact Author

Craig Wohlers

Matt DiCecca
Visit website