This study is significant because for the first time it examines associations between several types of cancers in a specific population and levels of exposure to the dust on the debris pile in lower Manhattan.
NY, NY (PRWEB) April 23, 2013
A comprehensive analysis of health data collected through the World Trade Center Health Program at the Icahn School of Medicine at Mount Sinai found cancer incidence rates statistically higher than expected among World Trade Center rescue and recovery workers. Elevations were seen for cancers at all anatomic sites in the human body combined, as well as for cancer of the thyroid, prostate cancer, hematopoietic (blood) and lymphoid cancer, and soft-tissue cancer. Cancer incidence rates were most highly elevated in very highly-exposed responders who were trapped in the dust cloud or who worked a significant number of days at the WTC site.
The study, “Cancer Incidence in World Trade Center Rescue and Recovery Workers, 2001-2008,” was based on self-reported health information combined with follow-up medical testing data from 20,984 consented participants in the WTC Health Program. A total of 575 cancers were diagnosed in 552 individuals. The findings, published online April 23 in the journal Environmental Health Perspectives, are concordant with previous research on firefighters conducted by the New York City Fire Department (FDNY) and with research on New York City residents conducted by the New York City Department of Health and Mental Hygiene’s WTC Health Registry.
“Previous studies have looked at cancer incidence rates after September 11, but did not report on associations according to levels of exposure. This study is significant because for the first time it examines associations between several types of cancers in a specific population – WTC rescue and recovery workers – and levels of exposure to the dust on the debris pile in lower Manhattan,” said study co-author Philip Landrigan, MD, MSc, FAAP, Dean for Global Health and the Ethel Wise Professor and Chair of the Department of Preventive Medicine at the Icahn School of Medicine at Mount Sinai.
“The findings of this study, while significant, should be interpreted with caution given the short follow-up and long latency period for most cancers; the intensive medical surveillance of this cohort by Mount Sinai researchers and our partners; and the small numbers of cancers at specific sites,” said Samara Solan, MD, an Instructor of Preventive Medicine at the Icahn School of Medicine at Mount Sinai and corresponding author of the study. “However, our findings strongly highlight the need for continued follow-up and medical surveillance of WTC responders.”
Cancers among 20,984 consented participants in the WTC Health Program were identified through linkage to state tumor registries in New York, New Jersey, Connecticut, and Pennsylvania. Standardized incidence ratios (SIRs) were calculated to compare cancers diagnosed in responders to predicted numbers for the general population. Multivariate regression models were used to estimate associations with degree of exposure.
Through linkage with the four state cancer registries, researchers identified 575 tumor diagnoses between September 11, 2011 and December 31, 2008 in 552 individuals from a total of 20,984 consented responders. Researchers estimated a 15 percent increase in all cancer sites combined among all responders (SIR 1.15; 95% CI: 1.06, 1.25) based on 575 cases diagnosed versus 498.8 expected (Table 2). Researchers also estimated statistically significant increases over expected registrybased incidence rates for thyroid cancer (SIR 2.39; 95% CI: 1.70, 3.27; 39 observed, 16.3 expected), prostate cancer (SIR 1.21; 95% CI: 1.01, 1.44; 129 observed, 106.8 expected), combined hematopoietic and lymphoid cancers (SIR 1.36; 95% CI: 1.07, 1.71; 74 observed, 54.5 expected), and soft tissue cancers (SIR 2.26; 95% CI: 1.13, 4.05; 11 observed, 4.9 expected). In addition, nonsignificant positive associations were estimated for nonHodgkin lymphoma (SIR 1.36; 95% CI: 0.96, 1.87; 8 observed, 6.6 expected) and kidney cancer (SIR 1.39; 95% CI: 0.95, 1.98; 31 observed, 22.2 expected). Fewer than six cases of several cancer types were observed, including mesothelioma and cancers of the pancreas.
About the World Trade Center Medical Monitoring and Treatment Program
The Mount Sinai-Irving J. Selikoff Center for Occupational and Environmental Medicine (COEM) has taken a lead in developing the World Trade Center Medical Monitoring and Treatment Program, which stands as the federal government’s principal public health response to 9/11 and continues to coordinate the NY-NJ Consortium of occupational medicine providers of program services.
The Program, with funding from the federal government, offers free, confidential medical and mental health evaluation, long-term monitoring and treatment for eligible WTC rescue, recovery and clean-up workers, including volunteers, who responded to the Sept. 11, 2001 terrorist attacks in New York City. Medical screening and annual medical monitoring examinations, as well as both out- and in-patient treatment services as may be needed for WTC-related medical and mental health conditions is being offered at a number of New York/New Jersey metro-area occupational medicine clinical centers and nationwide.
The Program also maintains data through two Data and Coordination Centers, one coordinated by the Icahn School of Medicine at Mount Sinai and one coordinated by the FDNY, complementing the latter agency’s matching service program for current and retired NYC Fire Dept. employees. Non-identifying data is periodically pooled and analyzed across the programs to expand the scientific understanding of health impacts resultant from WTC exposures, assure best practices of care for responders in need, and help inform future health response to such emergencies.
The Program’s Mount Sinai-coordinated Consortium of Clinical Centers of Excellence have medically screened over 30,000 WTC rescue and recovery workers and volunteers in all 50 states to date, since the program kicked off in July of 2002. The Consortium has also provided over 66,000 medical monitoring exams.
To determine eligibility, to enroll and/or for more information, WTC responders nationwide need only call into the programs hotline at 1-888-702-0630. The program maintains a website as well, which also lists participating services providers and clinical center locations, including those maintained by a NY/NJ metro-area Consortium.