Citicoline Supplementation May Significantly Slow Glaucoma Progression

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New Italian study found 500mg dose of Kyowa’s Citicoline may improve eye health.

Supplementation with citicoline may be beneficial in overall brain and eye health.
-- Sao Paolo Hospital Eye Clinic study

Citicoline is well known as a powerful brain health nutrient, and now is being counted as a supplement that may significantly slow the progression of visual acuity loss due to glaucoma.

Researchers at the Sao Paolo Hospital Eye Clinic at the University of Milan followed 41 patients with progressing glaucoma – a disease that damages the optic nerve and can lead to vision problems and blindness – over two years. The study targeted individuals with primary open-angle glaucoma (POAG), which is associated with increased eye pressure and a resulting loss of the vision field.

Participants were given an oral solution that contained 500mg of citicoline (Kyowa), and the results were astounding: the mean rate of progression dropped dramatically compared to the two years prior to the study. The study also found that there was a statistically significant decrease in intraocular pressure. It is not conclusive that citicoline alone is responsible for the results; however supplementation with citicoline may be beneficial in overall brain and eye health.

This study was recently published online in Ophthalmologica, 2013 April 23:219-226.* A link to the abstract can be found here -

  • Ottobelli L et al. Citicoline Oral Solution in Glaucoma: Is There a Role in Slowing Disease Progression? Ophthalmologica. 2013 Apr 23:219-226. [Epub ahead of print]

Citicoline is a vital nutrient that helps the brain generate electrical impulses, care for healthy brain cells, and protect neurons from free radical damage. It supports memory and cognitive function, while aiding in the synthesis and maintenance of cell membranes.

About Citicoline
Kyowa manufactures citicoline for various uses around the world. Citicoline is a substance found in every cell of the body and especially vital to brain health and eye health.* Citicoline is broken down during intestinal absorption and, after passing through the blood/brain barrier, is reconstituted in the brain as citicoline.* Citicoline is a water-soluble compound that supplies precursors for the synthesis of phospholipids, including phosphatidyl-choline, a major constituent of brain tissue*; helps maintain normal levels of acetylcholine, a chemical that regulates memory and cognitive function*; enhances communication between neurons*; supports visual function*; protects neural structures from free radical damage*; enhances metabolism and healthy brain activity*; and helps sustain healthy cellular mitochondria for sustained energy.* Kyowa’s branded for of Citicoline is called Cognizin®. Cognizin is also highly stable, GRAS, ultra-pure and allergen-free. For more information on Cognizin, visit
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

About Kyowa Hakko USA
Kyowa Hakko is an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. Kyowa is the maker of branded ingredients including Cognizin® Citicoline, Lumistor® L-Hydroxyproline, Setria® Glutathione, Pantesin® Pantethine, as well as Sustamine™ L-Alanyl-L-Glutamine.

Kyowa offers manufacturers and formulators one of the industry's most extensive lines of more than 50 amino acids and branch-chain amino acids, as well as nucleic acids, bio-products and fine chemicals. For more information, visit

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Dave Clifton
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