University Heights, OH (PRWEB) June 27, 2013
A new paper from Thailand (1) shows that melatonin improves the outcome when liver cancer is induced in hamsters. A new study (2) from Spain found that melatonin blocked the processes that control the development of new blood vessels needed for the liver cancer to grow. These studies help explain the 1999 study (3) from France that found that exposing rats to continuous light greatly increased the fraction of rats who developed liver cancer when given a carcinogen compared to those raised in normal 12 hours light 12 hous dark. Continuous light prevents the production of melatonin. This also may explain why the odds are about double of getting colon cancer, prostate cancer, rectal cancer, and pancreatic cancer for men working night shift according to a new paper (4) from Canada. Liver cancer was not included in this study. Working nights reduces the production of melatonin due to exposure to light.
In 2005, physicists at John Carroll University developed light bulbs that don’t produce blue light and amber eyeglasses that eliminate blue light. In 2001, it had been shown that it is primarily the blue rays in ordinary white light that suppress the production of melatonin--the sleep promoting, cancer fighting hormone. These products are available at http://www.lowbluelights.com along with filters for TV and computer screens including iPads and iPhones. Thousands of people have bought these products with a guarantee of money back if they don’t help. About 90% find they help them sleep. Possibly reducing the risk of cancer comes as a free bonus. Contact Dr. Richard L. Hansler at rhansler(at)jcu(dot)edu or call 216-397-1657
Pineal Res. 2013 May 22. doi: 10.1111/jpi.12068. [Epub ahead of print]
Melatonin inhibits cholangiocarcinoma and reduces liver injury in Opisthorchis viverrini-infected and N-nitrosodimethylamine-treated hamsters.
Umawadee L, Porntip P, Patcharee B, Chawalit P, Aroonsri P, Johns Nutjaree P, Lakhanawan C, Kitti I, Somchai P.
Br J Cancer. 2013 Jun 11. doi: 10.1038/bjc.2013.285. [Epub ahead of print]
Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells.
Carbajo-Pescador S, Ordoñez R, Benet M, Jover R, García-Palomo A, Mauriz JL, González-Gallego J.
Life Sci. 1999;64(26):2523-34.
The tumor promoting effect of constant light exposure on diethylnitrosamine-induced hepatocarcinogenesis in rats.
van den Heiligenberg S, Deprés-Brummer P, Barbason H, Claustrat B, Reynes M, Lévi F.
Am J Epidemiol. 2012 Nov 1;176(9):751-9. doi: 10.1093/aje/kws318. Epub 2012 Oct 3.
Night work and the risk of cancer among men.
Parent MÉ, El-Zein M, Rousseau MC, Pintos J, Siemiatycki J.