New Study on Latent EBV Is Consistent With Dr. Hanan Polansky’s Microcompetition Theory

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A study published in the journal ACS Chemical Biology on September 12, 2013 said that “Most EBV associated cancers contain viral DNA that exists predominantly as a latent infection (1).” The Center for the Biology of Chronic Disease (CBCD), is happy to see a new study that supports the theory of Microcompetition with Foreign DNA.

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We believe that it is time for a paradigm shift in the thinking of the medical community. 'Latent Viruses are Inactive.' This is a misconception that must be uprooted. - Greg Bennett, CBCD

Unlike the scientists at The Center for the Biology of Chronic Disease (CBCD), most members of the medical community still believe that latent viruses are inactive and therefore harmless. However, a recent study showed, as predicted by the Microcompetition with Foreign DNA Theory, that the latent EBV promotes tumor progression.

Note the emphasis the study authors place on the role of latent EBV in cancer.
“…latent infection can drive the formation of Burkitt’s lymphoma (BL), Hodgkin lymphomas, nasopharyngeal carcinoma (NPC), and gastric carcinoma (GC). Latent infection with EBV is a major cause of post-transplant lymphoproliferative disease in immunosuppressed patients and greatly enhances risk of developing non-Hodgkin and primary CNS lymphomas in the HIV-positive population (1).”

The authors are very clear. Latent EBV causes cancer. “Most EBV associated cancers contain viral DNA that exists predominantly as a latent infection in which only a limited set of viral genes are expressed. These latency associated genes are implicated in host-cell proliferation and survival, and latent EBV can directly promote tumor progression (1).”

Some doctors argue that latent viruses are inactive, that is, they show no transcription (production of proteins) and no shedding. Since the virus is inactive it is harmless.

In contrast, a paper entitled “Human Cytomegalovirus Persistence” published February 13, 2012 in the journal Cellular Microbiology, clearly says that latent viruses are active. “Both the chronic and latent states of infection contribute to HCMV persistence and to the high HCMV seroprevalence worldwide. The chronic infection is poorly defined molecularly, but clinically manifests as low-level virus shedding over extended periods of time and often in the absence of symptoms (2).” Note how the paper describes viral shedding during latency.

Moreover, another study said that “Transcripts and proteins encoded from a region encompassing the major immediate early region are detected in hematopoietic cells following infection in vitro as well as in latently infected individuals.” (Kondo et al., 1996 [3]; Landini et al., 2000 [4]). This means that there is transcription that occurs during latency.

“We believe that it is time for a paradigm shift in the thinking of the medical community. We continually hear from doctors that latent viruses are inactive, and therefore cause no harm. This is a misconception. Latent viruses are active. This misconception should be uprooted. It’s cost too many lives. Once the medical community realizes this is a misconception, it will have an easier time accepting the Microcompetition Theory.” – Greg Bennett, CBCD

The following is a simplified explanation of that theory. Dr. Hanan Polansky discovered that foreign DNA fragments, called N-boxes, cause most major diseases. When the foreign N-boxes belong to a virus, microcompetition between the viral DNA and the human DNA can lead to disease even when the virus is latent or the viral DNA is broken into pieces and cannot express proteins.

The CBCD is happy to see a new study from the Wistar Institute is consistent with the Microcompetition with Foreign DNA Theory proposed by Dr. Hanan Polansky (5).

To learn more about Dr. Hanan Polansky’s research and the Theory of Microcompetition with Foreign DNA, visit: http://www.cbcd.net

References:

(1)    http://www.ncbi.nlm.nih.gov/pubmed/24028149
(2)    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330195/
(3)    http://www.ncbi.nlm.nih.gov/pubmed/8855322/
(4)    http://www.ncbi.nlm.nih.gov/pubmed/10741618
(5)    http://www.cbcd.net

The CBCD is a research center recognized by the IRS as a 501(c)(3) non-for-profit organization. The mission of the CBCD is to advance the research on the biology of chronic diseases, and to accelerate the discovery of treatments.

The CBCD published the “Purple” book by Dr. Hanan Polansky. The book presents Dr. Polansky’s highly acclaimed scientific theory on the relationship between foreign DNA and the onset of chronic diseases. Dr. Polansky’s book is available as a free download from the CBCD website.

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Hanan Polansky
Center for the Biology of Chronic Disease (CBCD)
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