Our interest for the future is that we want to find better, more simple ways to increase intracellular levels of PIAS3 for malignant mesothelioma.
Raleigh, NC (PRWEB) September 26, 2014
New research appears to support the cancer-fighting power of curcumin, a polyphenol that is the primary component in the Asian spice, turmeric. Surviving Mesothelioma has just posted the full story on its website. Click here to read it now.
Doctors at the Case Comprehensive Cancer Center in Ohio and the Georg-Speyer-Haus Institute for Biomedical Research in Germany treated mesothelioma cells with a combination of curcumin and peptides extracted from PIAS3, a molecule shown to neutralize a cancer-triggering protein.
“Our interest for the future is that we want to find better, more simple ways to increase intracellular levels of PIAS3 for malignant mesothelioma through the use of synthetic PIAS3 peptide or curcumin analogs,” says Dr. Afshin Dowlati, a professor at Case Western Reserve School of Medicine.
With the help of curcumin, PIAS3 neutralized the effects of STAT3, a signaling protein linked to the start and growth of mesothelioma and other cancers. The findings appear in Clinical Cancer Research.
“These findings add to the growing body of research suggesting that this simple spice could hold important clues about how we can better combat mesothelioma and other intractable cancers,” says Alex Strauss, Managing Editor of Surviving Mesothelioma.
To learn more about curcumin and its links to cancer, see Component in Spice May Help Slow Mesothelioma Growth, now available on the Surviving Mesothelioma website.
Dabir, S et al, “Low PIAS3 Expression in Malignant mesothelioma is associated with increased STAT3 activation and poor patient survival”, August 14, 2014, Clinical Cancer Research, Epub ahead of print, http://clincancerres.aacrjournals.org/content/early/2014/08/14/1078-0432.CCR-14-1233.abstract
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