Airway Bacteria in Stable COPD Using qPCR and Culture Published by Dove Medical Press

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Quantitative polymerase chain reaction identifies a significant number of patients with potentially bacteria associated neutrophilic airway inflammation and disease who are not detected by traditional culture based methods.

The International Journal of Chronic Obstructive Pulmonary Disease has published the original research “Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function.”

As corresponding author Dr Mona Bafadhel says, “Bacteria can be detected by routine sputum culture and by molecular methods using real time PCR; this study aimed to investigate these bacteria detection methods and the relationship with inflammation in patients with COPD.”

Dr Bafadhel continues, “We showed that H. influenzae is a commonly detected pathogen both by culture and qPCR and that its persistence in the airway is associated with increased symptoms and increased inflammation. We discuss how H. influenzae may play a role in the pathogenesis of COPD.”

As Dr Richard Russell, Editor-in-Chief, explains “This is a highly rated paper on an important subject. The lung micro biome is a hot topic in COPD. This paper adds significantly to the data.”

The International Journal of Chronic Obstructive Pulmonary Disease is an international, peer-reviewed journal of therapeutics and pharmacology focusing on concise rapid reporting of clinical studies and reviews in COPD.

Dove Medical Press Ltd is a privately held company specializing in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine.

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Angela Jones
Dove Medical Press
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