New Report Explores the Genetic Basis of Pleural Mesothelioma, According to Surviving Mesothelioma

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Scientists say a BAP1 gene mutation may not be the only genetic explanation for why some asbestos-exposed people get mesothelioma and others do not.

The Genetics Behind Mesothelioma

Mesothelioma and Genetic Susceptibility

...some other tumor susceptibility or modified gene(s) [besides BAP1] may contribute to the high incidence of mesothelioma in this family.

Doctors in Philadelphia and Rome have published a report on eight pleural mesothelioma patients in a single Italian family. None of them had the inherited gene mutation called BAP 1 that is most often associated with mesothelioma in families. Click here to read the full article on the Surviving Mesothelioma website.

The eight Italian mesothelioma patients were all exposed to asbestos in their home. Scientists know that exposure and genetics can work together to raise mesothelioma risk, but are not sure what genes are to blame for this family’s illness.

“We discuss the possibility that some other tumor susceptibility or modified gene(s) [besides BAP1] may contribute to the high incidence of mesothelioma in this family,” writes study author Yuwaraj Kadariya of the Fox Chase Cancer Center in Philadelphia.

The family members had an even higher incidence of mesothelioma than workers heavily exposed to asbestos.

“Having a more complete picture of the genetics behind mesothelioma could potentially open new doors for treatment, screening, or even prevention of this deadly cancer cancer,” says Surviving Mesothelioma’s Managing Editor, Alex Strauss.

Read a more detailed explanation of the study and how it may relate to asbestos-exposed workers at Could Other Gene Mutations Be Behind Mesothelioma?, now available on the Surviving Mesothelioma website.

Cheung, M, et al, “An asbestos-exposed family with multiple cases of pleural malignant mesothelioma without inheritance of a predisposing BAP1 mutation”, July 30, 2015, Cancer Genetics, Epub ahead of print, http://www.sciencedirect.com/science/article/pii/S2210776215001623

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Cancer Monthy
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